Uop Lcc

Orochem Technologies, Inc.

Basf Pharma (callanish) Limited

Wisconsin Alumni Research Foundation

Aker Biomarine Antarctic As

Semba Biosciences, Inc.

Kazmira LLC

Alliedsignal Inc.

The United States of America As Represented by the Department of Energy

The Rockefeller University

Lanzatech New Zealand Limited

Semba Inc.

Basf Pharma Limited

Anil Rajaram Oroskar

Asha Anil Oroskar

Kurt M Vanden Bussche

Gavin Paul Towler

David W House

Adam Kelliher

Angus Morrison

Rakesh Vikraman Nair Rema

Abhilesh Agarwal

Laszlo T Nemeth

Santi Kulprathipanja

Babu Siddegowda Antharavally

Rusty M Pittman

Joseph A Kocal

Hayim Abrevaya

Michael A Schultz

James W Priegnitz

Lin Li

Robert T Sprague

Bipin Virpal Vora

Jeffery C Bricker

Suheil F Abdo

Lubo Zhou

Laurence O Stine

Stephen R Dunne

Gregory A Funk

Hermann A Zinnen

Asgeir Saebo

Beth McCulloch

Finn Myhren

Andrew Paul Wilke

Joel T Walenga

Nils Hoem

Robert Charles Mierendorf

Edith M Flanigen

Jason T Corradi

Peter R Pujado

James A Johnson

Leonid B Galperin

Frank S Modica

Paul R Kurek

YuPo J Lin

Chin-Hsiung Chang

Sarabjit Singh Randhava

Seth W Snyder

James R Lansbarkis

Simon H Hobbs

Robert C Mulvaney, Iii

Jamie Allen Hestekin

Michael P Henry

Stanley A Gembicki

Bradley James Larson

Xinjie Chen

Gautham Anil Oroskar

Faridedin Adel

Praneeth Dayanthe Edirisinghe

Anantha Krishna Mallia

Kunal Gulati

Xuejun Zang

Deepak Sharma

Feng Peng

Alexander B Smetana

Slobodan Milasinovic

Edwin J Crosby

Anthony Charles Grabski

Joerg Werner Baier

Kenneth J Stippich

Rahuljit Pal

Sanjay N Gandhi

W Patrick Dennler

Omkar M Kulkarni

Pravin Ramkrishna Ninawe

Massimo Sangalli

Daniel R Sioui

Michael Paul Rout

Julie A Zarraga

Kurt Vanden Bussche

Timur V Voskoboinikov

Alice Marie Havill

George Mack

Gary C Anderson

Herbert Edmund Paaren

Saurabh Paresh Parikh

Kenneth U Johnson

Anthony Joseph Escarcega

Rajesh Kumar Gupta

Richard A Janicki

Kerry S Crosby

Pat Palmese

Suzanne E Smith

Christine M Rayner

Ved Bhushan Gulati

Carl N Zenz

Robert L Zhou

Naveen S Sudharsan

Priyanka Anil Oroskar

Krishna Nagarajan Gopal

John P LaCava

James L Johnson

A method of removing THC and/or THCA from a mixture is provided, the mixture including at least one other cannabinoid. The method comprises passing a first feedstock stream through a first chromatographic resin arranged in a simulated moving bed (SMB) chromatography configuration to provide a primary raffinate stream, preparing a second feedstock stream, the second feedstock stream comprising the primary raffinate stream or a concentrated primary raffinate stream, and passing the second feedstock stream through a second chromatographic resin to provide an eluate stream, the eluate stream having less than 0.3 wt % THC on a solvent free basis. The cannabinoid products can be used in various pharmaceutical and nutraceutical applications.

Process for removing THC from cannabinoids

Embodiments of a method of purifying a lysophosphatidylcholine (e.g., LPC-DHA and/or LPC-EPA) from a composition containing the lysophosphatidylcholine and at least one impurity, e.g., from phospholipids, free fatty acids, triacylglycerols (TAGs), diacylglycerols (DAGs), monoacylglycerols (MAGs), glycerol, sterols, tocopherols, vitamin A, flavonoids, and minerals can use a continuous simulated moving bed process, a batch column chromatography method, or a single column to provide a purified composition of the lysophosphatidylcholine. The purified lysophosphatidylcholine (e.g., LPC-DHA and/or LPC-EPA) products can be used in various pharmaceutical and nutraceutical applications, e.g., for treating and/or preventing a neurological disease or disorder.

Process for purifying LPC-DHA and/or LPC-EPA using a chromatographic stationary phase and compositions thereof

The present invention provides improved processes for extracting and preparing lipids from biological sources for use in pharmaceuticals, nutraceuticals and functional foods.

Lipid compositions

Disclosed is a continuous process for the purification of steviol glycosides such as Rebaudioside D and/or Rebaudioside M extracted from the dried stevia leaves or extracted from a fermentation broth using continuous simulated moving bed processes and nanofiltration without the addition of organic solvents to obtain a purified steviol product comprising sweet steviol glycosides. The sweet steviol glycosides can be used as substitutes for caloric sweeteners in beverages and in other food items.

Method for producing purified steviol product using simulated moving bed chromatography

A method for purification and separation of cannabinoids, such as cannabidiol and tetrahydrocannabinol, e.g., from dried hemp andleaves can use a continuous simulated moving bed process, a batch column chromatography method, or a single column, and a combination of one or more of a sequence of purification steps including: filtration, decolorization, activation or decarboxylation, dewaxing, polishing, and crystallization to separate a cannabinoid from theplant and to provide various cannabinoid products. The cannabinoid products can be used in various pharmaceutical and nutraceutical applications.

Process for separating a constituent/cannabinoid using a chromatographic resin

The present invention relates generally to improved methods for the extraction and isolation of cannabinoids from hemp. More particularly, the present invention relates to a series of extraction and isolation processes employed to selectively enhance recovery of non-psychoactive cannabinoids and the like, frommaterials and extracts, while removing undesirable naturally occurring components that may be present including colorants, carbohydrates, sugars and waxes, and the like, as well as contaminants that may be present in source materials including bactericides, fungicides, insecticides, plant growth regulators, environmental pollutants, and processing aids, and the like. The present invention further relates to an isolate obtained using a series of extraction and isolation processes that has extremely high cannabinoid content present in a stable, flowable liquid form that is essentially free of detectable levels of psychoactive cannabinol components.

CBX extraction-isolation process

Disclosed is a continuous process for the purification of steviol glycosides such as Rebaudioside D and/or Rebaudioside M extracted from the driedleaves or extracted from a fermentation broth using continuous simulated moving bed processes and nanofiltration without the addition of organic solvents to obtain a purified steviol product comprising sweet steviol glycosides. The sweet steviol glycosides can be used as substitutes for caloric sweeteners in beverages and in other food items.

Disclosed is a continuous process for the purification of steviol glycosides extracted from the dried stevia leaves using continuous simulated moving bed processes and nanofiltration without the addition of organic solvents to obtain a purified steviol product comprising sweet steviol glycosides. The sweet steviol glycosides can be used as substitutes for caloric sweeteners in beverages and in other food items.

Continuous process for purification of steviol glycosides from stevia leaves using simulated moving bed chromatography

Disclosed is a continuous process for separating or extracting proteins from a low grade mixture of a protein of interest, other proteins, impurities, and salts in a continuous simulated moving bed separation process. The invention provides for direct extraction of heme protein and plant protein from a crude mixture of such proteins, other proteins, impurities and salts using the chromatographic technique of simulated moving bed (SMB) continuous chromatography. The SMB process combines the steps of feed loading, adsorbent washing, product elution, adsorbent regeneration, and adsorbent equilibration. The novel strong anion exchange resin adsorbent is a quaternary amine cross-linked microcellulose wherein the microcellulose is cross-linked with epichlorohydrin and the quaternary amine is 2,3-epoxypropyltrimethyl-ammonium chloride which exhibits selective adsorption of proteins and complete regeneration. Purified protein separated in this manner may provide human health benefits by providing greater medicinal and nutrition opportunities from low quality protein sources.

Adsorbent for chromatographic separation of proteins

A method for purification and separation of cannabinoids, such as cannabidiol and tetrahydrocannabinol, e.g., from the dried hemp andleaves can use a continuous simulated moving bed process and a combination of one or more of a sequence of purification steps including: filtration, decolorization, activation or decarboxylation, dewaxing, polishing, and crystallization to separate a cannabinoid from theplant and to provide various cannabinoid products. The cannabinoid products can be used in various pharmaceutical and nutraceutical applications.

Process for purification and separation of cannabinoids, from dried hemp and cannabis leaves

Disclosed is a method for purification and separation of cannabinoids, specifically cannabidiol and tetrahydrocannabinol, from the dried hemp andleaves using a combination of a sequence of purification steps including: filtration, decolorization, activation or decarboxylation, dewaxing, a continuous simulated moving bed process, polishing, and crystallization to separate cannabinoids from tetrahydrocannabinol and to provide phytocannabinoid rich oil and cannabidiol isolate. The cannabinoid products can be used in various pharmaceutical and nutraceutical applications.

Growing community of inventors

Oak Brook, IL, United States of America

Anil Rajaram Oroskar