Nxera Pharma UK Limited

Cellcentric Limited

Anil Patel

Miles Stuart Congreve

Giles Albert Brown

Benjamin Gerald Tehan

John Andrew Christopher

Sarah Joanne Bucknell

Mark Mills

Nigel Alan Swain

Anne Mary Stephenson

Stuart Thomas Onions

David Michel Adrien Taddei

David Cousin

Geraint Jones

Andrew William Phillips

Richard James Brown

Neil Anthony Pegg

Eric Sing Yuen Tse

David Kenneth Mycock

The disclosures herein relate to novel compounds of formula (I): and salts thereof, wherein W; X; Y; Z; R; R; Rand Rare defined herein, and their use in treating, preventing, ameliorating, controlling or reducing the risk of neurological or psychiatric disorders associated with orexin receptors.

Orexin 1 receptor antagonists

The disclosures herein relate to novel compounds of formula (1) and salts thereof, wherein V; W; X; Y; Z; R; R; R; Rand Rare defined herein, and their use in treating, preventing, ameliorating, controlling or reducing the risk of neurological or psychiatric disorders associated with orexin receptors.

Oxexin 1 receptor antagonists

A compound which is a benzimidazolyl isoxazole of formula (I): wherein: Rand R, which are the same or different, are each H or Calkyl; R, Rand R, which are the same or different, are each H or F; X is -(alk-, -alk-C(&#x2550;O)&#x2014;NR&#x2014;, -alk-NR&#x2014;C(&#x2550;O)&#x2014; or -alk-C(&#x2550;O)&#x2014;; Ris selected from &#x2014;S(&#x2550;O)R'; a 4- to 6-membered, C-linked heterocyclic group which is unsubstituted or substituted; and an N-linked spiro group of the following formula: Rand R, which are the same or different, are each H or Calkyl, or Rand Rform, together with the C atom to which they are attached, a Ccycloalkyl group; Rand R, which are the same or different, are each H, Calkyl, OH or F; Ris phenyl or a 5- to 12-membered, N-containing heteroaryl group and is unsubstituted or substituted; alk is Calkylene; R&#x2032; is Calkyl; and n is 0 or 1; or a pharmaceutically acceptable salt thereof. The compound has activity in modulating the activity of p300 and/or CBP and is used to treat cancer, particularly prostate cancer. 

Isoxazolyl substituted benzimidazoles

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Nottingham, United Kingdom

Anil Patel