Cell Therapeutics, Inc.

Amazon Technologies, Inc.

International Paper Company

Proteotech Inc.

Anil M Kumar

J Peter Klein

Gail E Underiner

Alistair J Leigh

John Michnick

Rama Bhatt

Amjad Hussain

David J Porubek

Diwakar Chakravarthy

Baoqing Gong

Ryan John Lohan

Stephen J Klaus

Glenn C Rice

John E Tulinsky

Julio Cesar Dos Santos Lins

Prabhu Anand Nakkeeran

Lance H Ridgers

David W Leung

Paul Woodson

Feng Hong

Rajagopala Reddy Duvvuru

Scott A Jenkins

Charles R Bredl

James William West

Alan D Snow

Paul David Franklin

James Caleb Kirschner

Thomas P Lake

Joel Cummings

Rajesh Viswanathan

Rishabh Animesh

Prashant Prahlad

Luke A Esposito

Marisa C Yadon

Naveen Anand Subramaniam

Sayali Suhas Deshpande

Bharath Swaminathan

Elisa Eiseman

Matthew John Hinkle

Brian Gouldsberry

Qingqing Xiao

Kelsey Hanson

Edward Vawter

Sami Azzam

Disclosed herein are synthesis methods for coelenterazine. Also disclosed are articles including the coelenterazine and coelenterazine derivatives. Representative absorbent articles include disposable diapers and adult incontinence products.

Synthesis of coelenterazine

This disclosure describes techniques for resolving discrepancies that occur to interrelated computing resources from computing resource drift. Users may describe computing resources in an infrastructure template. However, computing resource drift occurs when 'out-of-band' modifications are made to the computing resources and are not reflected in the infrastructure template. To resolve discrepancies between the infrastructure template and the out-of-band modifications to the computing resources, a notification may be output to a user account associated with the computing resources detailing the differences. An updated infrastructure template may be received that resolves the differences, such as by including configuration settings that reflect a current state of the computing resources. The computing resources may then execute a workflow using the updated template, such that the workflow is executed on all of the computing resources in a current state.

Resolving configuration drift for computing resource stacks

Techniques are described for identifying 'out-of-band' modifications to an interrelated set of computing resources, also referred to herein as a computing resource stack, that was provisioned at a service provider network using an infrastructure modeling service. An infrastructure modeling service generally allows users to describe a computing resource stack in a text file or other type of descriptive representation, referred to herein as an infrastructure template, and to automatically provision computing resource stacks defined in templates at a service provider network. Users may at times make so-called out-of-band modifications to one or more computing resources of a provisioned computing resource stack, either inadvertently or in response to time-sensitive demands, where an out-of-band modification is made outside of the infrastructure modeling service.

Detecting configuration drift for computing resource stacks

This disclosure describes techniques for centralizing the management of computing resources that are provisioned across multiple service provider networks by infrastructure modeling services. A service provider network may host or provide a centralized management service that supports an open source framework that provides users, or developers, with a unified development interface to manage computing resources that are provisioned in different service provider networks. The unified development interface of the host service provider network may provide users with a meta schema or language format to create infrastructure schemas for modeling, provisioning, and operating computing resources across service provider networks that are managed by different service providers. Additionally, the host service provider network may provide an open provider registry where developers of infrastructure schemas may store and publish infrastructure schemas for the different service provider networks to share computing resource types with other developers or users of cloud-based services.

Centralized management of computing resources across service provider networks

First audit information corresponding to a first set of log entries associated with a transformation performed on first data is obtained, where the first audit information includes a first commutative result produced by applying a commutative function to object identifiers associated with the first set of log entries. Second audit information corresponding to a second set of log entries associated with the transformation performed on second data is obtained, with the second data being a different representation of the first data and where the second audit information includes a second commutative result produced by applying the commutative function to object identifiers associated with the second set of log entries. The first commutative result is compared with the second commutative result to validate whether the second data matches the first data. One or more actions are performed depending on whether the second data is the successful transformation of the first data.

Audit correctness of asynchronous batch transformation systems

Compounds and their pharmaceutically acceptable salts for treatment of &#x3b2;-amyloid diseases, such as observed in Alzheimer's disease and synucleinopathies, such as Parkinson's disease.

Caffeinated compounds and compositions for treatment of amyloid diseases and synucleinopathies

The invention relates to aryl triazines and uses thereof, including to inhibit lysophosphatidic acid acyltransferase &#x3b2; (LPAAT-&#x3b2;) activity and/or proliferation of cells such as tumor cells.

Aryl triazines as LPAAT-&#x3b2; inhibitors and uses thereof

The invention provides new processes for preparing polyglutamic acid-therapeutic agent conjugates for clinical development and pharmaceutical use, and polyglutamic acid-therapeutic agent conjugates prepared by these processes.

Manufacture of polyglutamate-therapeutic agent conjugates

Disclosed are compounds having selective hydrolytic potential. The disclosed compounds are useful as compounds having selective stability and are capable of undergoing programmed hydrolysis in biologic systems.

Compounds having selective hydrolytic potentials

Novel heterocyclic compounds having a six membered ring structure fused to a five membered ring structure are found to be useful for the treatment and prevention of symptoms or manifestations associated with disorders affected by Interleukin-12 ('IL-12') intracellular signaling, such as, for example, Th1 cell-mediated disorders. The therapeutic compounds, pharmaceutically acceptable derivatives (e.g., resolved enantiomers, diastereomers, tautomers, salts and solvates thereof) or prodrugs thereof, have the following general formula:Each X, Y and Z are independently selected from a member of the group consisting of C(R), N, N(R) and S. Each R, Rand Ris substituted or unsubstituted and is independently selected from a member of the group consisting of hydrogen, halo, oxo, Calkyl, Chydroxyalkyl, Cthioalkyl, Calkylamino, Calkylaminoalkyl, Caminoalkyl, Caminoalkoxyalkenyl, Caminoalkoxyalkynyl, Cdiaminoalkyl, Ctriaminoalkyl, Ctetraaminoalkyl, Caminotrialkoxyamino, Calkylamido, Calkylamidoalkyl, Camidoalkyl, Cacetamidoalkyl, Calkenyl, Calkynyl, Calkoxyl, Calkoxyalkyl, and Cdialkoxyalkyl.

Therapeutic compounds for inhibiting interleukin-12 signals and method for using same

Disclosed are compounds having selective hydrolytic potential. The disclosed compounds are useful as compounds having selective stability and are capable of undergoing programmed hydrolysis in biologic systems. The disclosed compounds have a structure of formula I:

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Seattle, WA, United States of America

Anil M Kumar