Council of Scientific and Industrial Research

Anil Kumar Tripathi

Abhishek Kumar Singh

Naibedya Chattopadhyay

Sabyasachi Sanyal

Harish Kumar

Atul Kumar

Arun Kumar Trivedi

Srikanta Kumar Rath

Anagha Gurjar

Jiaur Rahaman Gayen

Nidhi Singh

Riyazuddin Mohammed

Ravishankar Ramachandran

Sonal Shree

Dipak Datta

Sourav Chattopadhyay

Tahseen Akhtar

Shailendra Kumar Dhar Dwivedi

Sapana Kushwaha

Manisha Yadav

Bandana Chakravarti

Shikha Dubey

Jay Sharan Mishra

Kiran Lata

Arun Kumarv Trivedi

Jawahar Lal

The present invention relates to method of treating chronic myeloid leukemia (CML) or drug resistant CML comprising, administering to human being or any other mammal or animal in need thereof, a therapeutically effective amount of Clofazimine (CFZ) or its pharmaceutically acceptable derivative, analogue, salt or composition; or a combination of a therapeutically effective amount of Clofazimine (CFZ) or its pharmaceutically acceptable derivative, analogue, salt or composition with a tyrosine kinase inhibitor (TKI). The invention also provides the kit for treatment of CML or drug resistant CML.

Combination of clofazimine and imatinib for effective therapy of drug-resistant myeloid leukemia

The present invention relates to substituted aryl naphthyl methanone oximes of general formula (I), their process for preparation and their derivatives, salts, pharmaceutical composition thereof and their use in treatment of chronic myelogenous leukemia, acute myelogenous leukemia, lymphoma, multiple myeloma, solid tumor forming cell-lines including such as breast cancer, endometrial cancer colon cancer, prostate cancer and killing of drug resistant cancer stem cells, as subject in need thereof. 

Aryl naphthyl methanone oxime(s) and process for preparation thereof

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Uttar Pradesh, India

Anil Kumar Tripathi