Taxis Pharmaceuticals, Inc.

Bausch-lomb Incorporated

Anil Kumar Soni

Ravi Ponnaiah

Pullarao Seelam

Thrisulapani Korrakuti

Ajit K Parhi

Nareshkumar Jain

Sanjeevani Ghone

Fu-An Kang

Siva Rami Reddy Athunuri

Ajit S Parhi

Arthur E Harms

Sudhakar Sunkari

Savi Rami Reddy Athunuri

Ramakrishnan Arul

The invention provides synthetic intermediates and synthetic processes that are useful for preparing the antibacterial agent TXA709:

Synthetic processes and synthetic intermediates

The invention provides synthetic intermediates and synthetic processes that are useful for preparing the antibacterial agent TXA709: 

The invention provides synthetic processes and synthetic intermediates that can be used to prepare a compound of formula (I): or a salt thereof.

Synthetic processes and intermediates

A process of preparing a quinolone carboxylic acid or its derivatives having Formula I, Ia, Ib, or IV, as shown herein, comprises using a starting quinolone that already has one or more desired substituents at one or more particular positions on the quinolone ring and preserving the orientation of such substituents throughout the synthesis. The present process comprises fewer steps than prior-art processes. The present process also can include a simple separation of a desired enantiomer of the quinolone carboxylic acid or its derivatives from the enantiomeric mixture. Pharmaceutical compositions comprising fluoroquinolones prepared by the present process can be used effectively against a variety of microbial pathogens.

Quinolone carboxylic acids, derivatives thereof, and methods of making and using same

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Hyderabad Telangana, India

Anil Kumar Soni