Council of Scientific and Industrial Research

Ranbaxy Laboratories, Inc.

Anil Kumar Saxena

Neelima Sinha

Sanjay Kumar Jain

Nitya Anand

Anita Mehta

Madhur Ray

Gyanendra Kumar Patnaik, Deceased

Ram Mohan Saxena

Mangal Prasad Dubey

Zeeshan Fatima

Chandishwar Nath

Madhu Dikshit

Stuti Gaur

Anshuman Dixit

Zahid Ali

William Rascan Surin

Kapil Kappor

Kanta Bhutani

Mohammed Salim Ansari

Neeraj Shakya

Rakesh Shukla

Santoshkumar Tota

Kuldeep Kumar Roy

The present invention relates to novel substituted 1,2,3,4-tetrahydroquinolin-7-yl carbamates, their preparation, and use as therapeutic agents, particularly in the prevention or treatment of neurodegenerative or Alzheimer's disease, or senile dementia, or memory disturbances, and more particularly to the prevention, treatment and amelioration of Alzheimer's disease with the novel substituted 1,2,3,4-tetrahydroquinolin-7-yl carbamates, which act as inhibitors of central cholinesterase enzymes, particularly acetylcholinesterase (AChE) following the indirect cholinomimetic pathway. The present invention particularly relates to compounds of formula A: Formula A wherein R=alkyl, aryl, substituted aryl; R=H, methyl; R=H, alkyl, alkenyl, alkynyl, aralkyl, substituted aralkyl, aryl, heteroaryl. 

Substituted 1, 2, 3, 4-tetrahydroquinolin-7-yl carbamates as acetylcholinesterase inhibitors for treatment of Alzheimer's disease

The present invention relates to new substituted carbamic acid quinoline-6-yl esters of formulae 1 and 2 where R=alkyl, aryl; R=H, alkyl, aralkyl useful as acetylcholinesterase inhibitors, and which show potent antiacetylcholinesterase activity and have potential therapeutic use for prevention or cure of acetylcholinesterase related disorders including peripheral as well as central nervous system. 

Substituted carbamic acid quinolin-6-yl esters useful as acetylcholinesterase inhibitors

The present invention relates to antithrombotic compounds 2-alkyl aryl sulphonyl-1,2,3,4-tetrahydro-9H-pyrido(3,4-b)indole-3-carboxylic acid esters/amides, pharmaceutically acceptable salts and compositions thereof to be used in the treatment of intravascular thrombosis such as myocardial ischemia and stroke. The compound has the following general structure wherein R represents methyl ester or amide and Rrepresents alkyl, aryl and heteroaryl moiety.

2-Alkyl/aryl sulphonyl-1,2,3,4-tetrahydro-9H-pyrido (3,4-b) indole-3-carboxylic acid esters/amides useful as antithrombotic agents

The present invention relates to certain novel piperazine derivatives having protracted uro-selective &agr; -adrenoceptor antagonistic activity exceeding those of previously described compounds. The compounds of the present invention hold promise for treating benign prostratic hyperplasia (BPH). This invention also relates to methods for making the novel compounds, pharmaceutical compositions containing the compounds, and methods of treating benign prostatic hyperplasia using the compounds.

1-(4-Arylpiperazin-1-yl)-&ohgr;-&lsqb;N-(&agr;,&ohgr;-dicarboximidoL)&rsqb;-alkanes useful as uro-selective &agr;1-adrenoceptor blockers

Novel piperzine derivatives substituted on one nitrogen by an aromatic system and on the other nitrogen by (2,5-dioxopyrrolidin)-1-yl) alkanes or (2,6-dioxopiperidin-1-yl) alkanes have been found to exhibit selective &agr; adrenergic activity. The compounds are useful for treatment of disease conditions, such as peripheral vascular disease, congestive heart failure, hypertension and especially benign prostatic hypertrophy.

1-(4-arylpiperazin-1-yl)-&ohgr;-&lsqb;N-(&agr;,&ohgr;-dicarboximido)&rsqb;-alkanes useful as uro-selective &agr;1-adrenoceptor blockers

1-(4-arylpiperazin-1-y1)-&ohgr;-&lsqb;N-(&agr;,&ohgr;-dicarboximido)&rsqb;-alkanes useful as uro-selective &agr;1-adrenoceptor blockers

A chemical compound and composition of Formula 1: ##STR1## wherein Ar represents a phenyl ring substituted by the groups like halo, alkoxy, alkyl or heteroaryl, n=1 or n=2; said compounds and compositions as being useful therapeutic agents for hypertension, ischemic, cardiovascular and other adrenergic receptor related disorders.

1-[4-arylpiperazin-1-yl]-3-[2-oxopyrrolidin/piperidin-1-yl]propanes and

Novel piperzine derivatives substituted on one nitrogen by an aromatic system and on the other nitrogen by (2,5-dioxopyrrolidin)-1-yl) alkanes or (2,6-dioxopiperidin-1-yl) alkanes have been found to exhibit selective .alpha..sub.1A adrenergic activity. The compounds are useful for treatment of disease conditions, such as peripheral vascular disease, congestive heart failure, hypertension and especially benign prostatic hypertrophy.

1-(4-arylpiperazin-1-yl)-.omega.-[n-(.alpha...

The invention relates to a process for the synthesis of 1-[4-Arylpiperazin-1-yl]-3-[2-oxopyrrolidin/piperidin-1-yl]propanes used as potential therapeutic agents for hypertension, ischemia, cardiovascular and other adrenergic receptors related disorders, having general formula 1 ##STR1## wherein Ar represents a phenyl ring substituted by the groups like halo, alkoxy, alkyl or heteroaryl, n=1 or n=2; a process of preparing said compounds and a method of treating hypertension, ischemia, cardiovascular and other adrenergic receptors related disorders.

Methods for preparing

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Anil Kumar Saxena