University of Iowa Research Foundation

Other

Anil K Chauhan

Andrew A Pieper

Thomas Schnell

Salam F Rahmatalla

Enrique C Leira

Nirav A Dhanesha

The disclosed apparatus, systems and methods relate to devices, systems and methods for improving thrombolysis via synergetic application of thrombolytics with physical factors, such as in acute ischemic stroke patients. Vibration in the low (0.5-120 Hz) frequency range is synergistic with tissue plasminogen activators (rtPA), significantly improving the effectiveness of thrombolysis without impairing blood brain barrier permeability. Administration of low frequency vibration combined with rtPA improve acute ischemic stroke outcomes.

Replication or mitigation of low frequency vibration and other physical factors to enhance the effect of thrombolysis on patients with ischemic stroke

The invention provides a method and kits for inhibiting integrin &#x3b1;9&#x3b2;1 activity comprising contacting integrin &#x3b1;9&#x3b2;1 or a binding partner of integrin &#x3b1;9&#x3b2;1 with an isolated anti-integrin &#x3b1;9 inhibitor, wherein the integrin &#x3b1;9&#x3b2;1 activity is inhibited. In certain aspects, the present invention provides a novel intervention by targeting integrin &#x3b1;9&#x3b2;1 with a functional blocking inhibitor (e.g., peptides or antibodies) to limit brain damage following reperfusion after ischemic stroke.

Methods of inhibiting integrin &#x3b1;9&#x3b2;1 activity

A process for the preparation of active receptor and receptor complex fractions from cell lines expressing cell surface receptors which comprises applying ultrasonication to provide said expression to the cells in an aqueous (detergent free or substantially detergent free) composition.

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Iowa City, IA, United States of America

Anil K Chauhan