Hewlett-Packard Development Company, L.p.

The Scripps Research Institute

Hewlett Packard Enterprise Development LP

Hewlett-Packard Company

Wyebot, Inc.

Broadridge Investor Communication Solutions, Inc.

Anil Gupta

Roger D Sands

Arnab Kumar Chatterjee

Peter G Schultz

Sung-Ju Lee

Souvik Sen

Hank Michael James Petrassi

Pierre Trudeau

Case W McNamara

Jung Gun Lee

Jason Thomas Roland

Manfred R Arndt

Richard H Blanchette

Yannick Koehler

Gilbert Moineau

Fei Zhou

Louis E Pereira

Martin Bouchard

Vincent Ma

John S Balian

Wil Joseph Andahazy

David V Baker

Federico C Beasley

Olga Vladimirovna Zatolochnaya

Anders Mikal Eliasen

Timothy Wells

Fréderic D Mouveaux

Hien Nguyen

Jian Jeffrey Chen

Junko Tamiya

Luke L Lairson

Raul Herman Etkin

Alex Magary

William Vernier

Patricia Rosch

Manoj Kumar

Brigitte Tuller

Larry Kunz

Thomas S Stefanski

Ana Maria Gamo Albero

Emily Chin

Ramkumar Modukuri

Chenguang Yu

Alireza Rahimi

Elshan Nakath

Wrickban Mazumdar

Katy Wilson

Mili Hoxha

James Pedroarena

Jacqueline Malvin

Sourav Ghorai

Armen Nazarian

Sean Joseph

Gennadii Grabovyi

Frank Weiss

Lirui Song

Laura Riva

Karen Wolff

Yuyin Liu

Ashley Woods

Malina A Bakowski

Neechi Okwor

Shuangwei Li

Thomas F Rogers

Frederic D Mouveaux

Craig Leclair

Jeffrey Levering

John S Bailan

Provided herein are compounds of Formula (I), their pharmaceutically acceptable salts, and their pharmaceutical compositions: wherein R, R, R, R, R, R, and A are defined in the present disclosure. The compounds are potent inhibitors of the main protease (M) of severe acute respiratory syndrome Coronavirus-2 (SARS-CoV-2), and they are useful in treating or preventing COVID-19 in a subject.

Protease inhibitors for treatment of coronavirus infections

The invention provides compounds having STimulator of INterferon Genes (STING) agonistic bioactivity that can be used in the treatment of tumors in patients afflicted therewith. The compounds are of formula (I): as defined herein. Compounds for practice of a method of the invention can be delivered via oral delivery for systemic exposure, as well as delivered intratumorally. Antitumor therapy using a compound of formula (I) can further comprise administration of an effective dose of an immune-checkpoint targeting drug.

Agonists of stimulator of interferon genes sting

Provided herein are compounds, compositions and method of using thereof to treat or prevent malaria.

Antimalarial compositions and uses thereof

Described herein are techniques for performing a channel scan based on a mobility state of a device. The mobility state of a device relative to an access point may be determined using time-of-flight information. A channel scan may be performed based on the mobility state determination.

Channel scan based on mobility state

Computer-implemented methods and systems are disclosed for optimizing the performance of wireless networks by automatically capturing wireless traffic and other radio frequency (RF) signal data in the network and analyzing the data to identify network anomalies and to determine one or more solutions, without human intervention.

Methods and systems for optimizing wireless network performance using behavioral profiling of network devices

Described herein are techniques for selecting a subset of access points. In an example, a wireless access point stores a plurality of unique keys, each unique key being associated with a respective device. The access point advertises a first service set identifier, the first service set identifier requiring authentication of a device requesting connection at a remotely located authentication server. The access point monitors a connection to the remotely located authentication server, and, in response to the connection going down, advertising a second service set identifier, the second service set identifier requiring authentication of a device requesting connection using the unique key associated with the device requesting connection.

Advertising multiple service set identifiers

Described herein are techniques for selecting a subset of access points. In an example, time-of-flight information and signal strength information associated with a device may be received from multiple access points. A subset of the access points may be selected based on the time-of-flight information, signal strength information, and load information. The subset of access points may be instructed to respond to a probe request from the device.

Selecting a subset of access points

Methods, devices, and machine readable media are provided for transmission in a network with active and sleeping clients. Some examples can include transmitting a first multicast stream of data in response to an active wireless client being associated with the wireless network device at a particular time. The method can include transmitting a second multicast stream of the data after the first multicast stream in response to a sleeping wireless client being associated with the wireless network device at the particular time and in response to a delivery traffic indication message count expiring. The first and/or second multicast streams of the data can be retransmitted a number of times (e.g., at different data rates). An active/sleep status can be maintained for the wireless clients. A unicast stream can be transmitted when the number of clients does not exceed a threshold.

Transmission in a network with active and sleeping clients

To enable a network apparatus to detect L3 roaming users and to take appropriate forwarding actions, L3 knowledge is introduced inside an L2 bridge forwarding table in the network apparatus. As a client moves from a subnet associated with a first network element to a subnet associated with the network apparatus, a determination is made regarding whether the client is roaming by evaluating a source IP address within a L3 packet header within a first frame received at the network apparatus. If, as a result of the evaluating step, it is determined that the client is roaming, the L2 bridge forwarding table is configured to include a source MAC address of the client together with information identifying a destination interface for use in directing client data traffic back towards the subnet associated with the first network element.

Network apparatus enabling roaming across subnets

Systems, methods, and devices are provided for an adaptive wireless network. A wireless network device for an adaptive wireless network can include an application specific integrated circuit (ASIC) including logic and memory resources coupled to the ASIC. The logic can store information received from a number of clients associated with the wireless network device regarding capabilities of the number of clients in the memory resources. The logic can adapt a guard interval and/or a channel width for transmission of a data stream according to capabilities of a number of clients associated with the wireless network device.

Adaptive wireless network

A wireless node receives a beacon from a wireless access point. The beacon includes a wireless protocol time synchronization function (TSF) timestamp generated with reference to a global clock for a network. The wireless node synchronizes a counter according to the TSF timestamp. The wireless node receives a global timing offset (GTO) packet from the wireless access point and combines the GTO packet with a counter value to generate a global timestamp.

Synchronization in a wireless node

To enable devices to detect L3 roaming users and to take appropriate forwarding actions, L3 knowledge is introduced inside a bridge in a non-intrusive way. In particular, as a client moves from a subnet associated with a first network element to a subnet associated with a second network element, a determination is made regarding whether the client is roaming. This is done by evaluating a source IP address within a L3 packet header within a first frame received at the second network element. If, as a result of the evaluating step, it is determined that the client is roaming, an L2 bridge forwarding table in the second network element is configured to include a source MAC address of the client together with information identifying at least a destination interface for use in directing client data traffic back towards the subnet associated with the first network element. The first frame is then forwarded. In one embodiment, the traffic is directed back towards the subnet associated with the first network element via a GRE encapsulation tunnel, although any convenient tunneling mechanism can be used. According to another feature, given information cached at the foreign access point is used to enable the roaming client to continue to seamlessly receive inbound traffic prior to or during the configuration of the L2 bridge forwarding table (i.e., before any outbound traffic is actually sent from the client).

Seamless roaming across wireless subnets using source address forwarding

A fast roaming (handoff) service is provided for a WLAN infrastructure. A given mobile station (STA) obtains a pairwise master key (PMK) when it associates with an access point (AP) in the infrastructure. A neighbor graph identifies prospective APs to which the STA may then roam. At initialization, preferably the neighbor graph is fully-connected (i.e., each AP is assumed to be connected to every other AP). The PMK (obtained by the STA initially) is shared proactively with the neighbor APs as indicated in the neighbor graph. Thus, when the STA roams to a neighbor AP, because the PMK is already available, there is no requirement that the STA initiate a real-time request to an authentication server to re-associate to the new AP. Further, the new AP causes an update to the neighbor graph information implicitly by simply issuing a notification that it is now handling the STA that arrived from the prior AP; in this manner, the prior AP is confirmed as a neighbor, but there is no requirement for any inter-AP dialog before a given neighbor graph is updated. As roaming occurs the neighbor graph is pruned down (to reflect the actual neighbor AP connections) using the implicit notification data.

Fast roaming in a wireless network using per-STA pairwise master keys shared across participating access points

Growing community of inventors

Shrewsbury, MA, United States of America

Anil Gupta