Council of Scientific and Industrial Research

Other

Department of Biotechnology

Anil Chatterji

Pradeep Bhaskar Parab

Ramesh Ramchandra Bhonde

Ehrlich Desa

Vinod Kumar Singh

Parameswaran Perunninakulath Subrayan

Gyan Chandra Mishra

Mohan Ramachandran Wani

Mohan Ramachandra Wani

Kanury Venkata Subba Rao

Venkatasamy Manivel

Ramasamy Vijaya Anand

Debasis Mitra

This invention relates to a novel class of acidic amino acid/dicarboxylic acid derivatives (sulfonic acid/sulfate derivatives of naturally occurring amino acids and their amides) useful as inhibitors of osteoclastogenesis. The invention also provides methods of using the novel class of acidic amino acid/dicarboxylic acid derivatives of the general formula ZOC&#x2014;(CRR)&#x2014;COOH, wherein: m=2, 3 or 4; Z is OH or NH; one R in the compound is from the group consisting of SOH, OSOH, CH&#x2014;SOH, CH&#x2014;OSOH, and NHSOH, and the remaining Rs are H or NH, for inhibition of osteoclastogenesis.

Method and composition for treating osteoporosis

A process for obtaining a substance with growth promoting activity that includes the step of isolating perivitelline fluid from a fertilized egg of a horseshoe crab. Also, a process for proliferating cells including the steps of isolating perivitelline fluid from a fertilized egg of a horseshoe crab and growing the cells in the presence of the isolated perivitelline fluid.

Process for proliferation and differentiation of rat ascinar cells

The present invention relates to a process for the cure and control of Diabetes mellitus using natural products isolated from

Process for the cure and control of Diabetes mellitus using natural products from Perna viridis

The invention provides a compositions comprising mussel hydrolysate from Indian green mussel, e.g.,. The invention further provides methods of inhibiting or preventing osteoclast formation and/or bone resorption comprising administration of mussel hydrolysate from Indian Green to an animal or human. The compositions of the invention are non-toxic to other cells. Additionally, the invention provides processes for extracting mussel hydrolysate from Indian green mussel, e.g.,

Pharmaceutical composition useful for inhibition of osteoclast formation and a process for the extraction of mussel hudrolysate from indian green mussel

The present invention provides a process for large scale in vitro production of amoebocytes of Indian Horseshoe Crab ( ) ( ) from dissected gill flaps of , in Leibovitz L- culture medium concentration (2&times;), to provide enhanced generation of amoebocytes. The process comprises the steps of: dissecting gill flaps of ; washing the gill flaps with an antibiotic solution followed by alcohol; culturing the gill flaps in tissue culture plates of sterile saline on a Rocker platform; culturing further the gill flaps in Leibovitz L- culture medium (2&times;); purging the gill flaps with Tween 80 solution; and purging again the gill flaps with horseshoe crab serum, while keeping the gill flaps in the culture medium viable for 90 days by feeding with fresh medium at an interval of 10-15 days to enable the enhanced release of amoebocytes both within and outside the gill flaps.

In vitro production of amoebocytes from tachypleus gigas in leibovitz culture medium

The present invention relates to the use of Indian Green Mussel ( ) as a source of anti-HIV activity. More particularly, the present invention relates to the use of an extract of Indian Green Mussel ( ) as a source of anti-HIV activity in vitro.

Growing community of inventors

Goa, India

Anil Chatterji