Biogal Gyogyszergyar Rt.

Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag

Aniko Tedges

Istvan M Szabo

Istvan Barta

Janos Erdei

Karoly Albrecht

Valeria Szell

Julianna Mozes Nee Suto

Ildiko Lang

Eva Gulyas

Gabor Balogh

Magdolna Petroczki

A procedure for the preparation of pseudomonic acid A comprising submerged cultivation of abacterium strain capable of biosynthesis of the substantially pure pseudomonic acid A in aerated conditions via fermentation; and isolation of the desired compound is disclosed. In particular, the procedure of the present invention comprises cultivation of thesp. bacterium strain No. 19/26 deposited under accession No. NCAIM(P)B 001235 in the National Collection of the Agricultural and Industrial Microorganisms, Budapest, Hungary, or its pseudomonic acid A-producing mutant or variant, on a medium at a temperature of between about 20&#xb0; C. and 30&#xb0; C. containing organic nitrogen and carbon sources and, optionally, mineral salts.

Process for the preparation of pseudomonic acid a antibiotic by microbiological method

A procedure for the preparation of pseudomonic acid A comprising submerged cultivation of a Pseudomonas bacterium strain capable of biosynthesis of the substantially pure pseudomonic acid A in aerated conditions via fermentation; and isolation of the desired compound is disclosed. In particular, the procedure of the present invention comprises cultivation of the Pseudomonas sp. bacterium strain No. 19/26 deposited under accession No. NCAIM(P)B 001235 in the National Collection of the Agricultural and Industrial Microorganisms, Budapest, Hungary, or its pseudomonic acid A-producing mutant or variant, on a medium at a temperature of between about 20&deg; C. and 30&deg; C. containing organic nitrogen and carbon sources and, optionally, mineral salts.

Process for the preparation of pseudomonic acid A antibiotic by microbiological method

Growing community of inventors

Budapest, Hungary

Aniko Tedges