Arcus Biosciences, Inc.

Anh Thu Tran

Jay Patrick Powers

Manmohan Reddy Leleti

Jaroslaw Kalisiak

Debashis Mandal

Erick Allen Lindsey

Joel Worley Beatty

Steven Donald Jacob

Tezcan Guney

Xuelei Yan

Brandon Reid Rosen

Kenneth Victor Lawson

Jenna Leigh Jeffrey

Samuel Lawrie Drew

Yongli Su

Guillaume Mata

Balint Gal

Artur Karenovich Mailyan

Clayton Hardman

Zhang Wang

Kai Yu

Matthew Epplin

Jeremy Thomas Andre Fournier

Hyunyoung Moon

Karl T Haelsig

Rebecca Louise Grange

Eric Newcomb

Corinne Nicole Foley

Rhiannon Thomas-Tran

Laurent Pierre Paul Debien

Jeremy Fournier

Eric Thomas Newcomb

Compounds that are inhibitors of at least one of ARG1 and ARG2, and compositions containing the compounds and methods for synthesizing the compounds, are described herein. The use of such compounds and compositions for the treatment of a diverse array of diseases, disorders, and conditions, including cancer- and immune-related disorders that are mediated, at least in part, by ARG1 and ARG2 are also described herein.

Inhibitors of ARG1 and/or ARG2

Compounds that inhibit HIF-2α, and compositions containing the compound(s) and methods for synthesizing the compounds, are described herein. Also described are the use of such compounds and compositions for the treatment of a diverse array of diseases, disorders, and conditions, including cancer- and immune-related disorders that are mediated, at least in part, by HIF-2α.

Tetralin and tetrahydroquinoline compounds as inhibitors of HIF-2alpha

Compounds that are inhibitors of at least one of the ARG1 and ARG2, and compositions containing the compounds and methods for synthesizing the compounds, are described herein. The use of such compounds and compositions for the treatment of a diverse array of diseases, disorders, and conditions, including cancer- and immune-related disorders that are mediated, at least in part, by ARG1 and ARG2 are also described herein.

Arginase inhibitors

Compounds, such as compounds having Formula (I): wherein each variable is as described herein, that modulate the conversion of AMP to adenosine by 5′-nucleotidase, ecto, and compositions containing the compounds and methods for synthesizing the compounds, are described herein. The use of such compounds and compositions for the treatment and/or prevention of a diverse array of diseases, disorders and conditions, including cancer- and immune-related disorders, that are mediated by 5′-nucleotidase, ecto is also provided.

CD73 inhibitors

Compounds that inhibit HIF-2&#x3b1;, and compositions containing the compound(s) and methods for synthesizing the compounds, are described herein. Also described are the use of such compounds and compositions for the treatment of a diverse array of diseases, disorders, and conditions, including cancer- and immune-related disorders that are mediated, at least in part, by HIF-2&#x3b1;.

Tetralin and tetrahydroquinoline compounds as inhibitors of HIF-2&#x3b1;

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Union City, CA, United States of America

Anh Thu Tran