Sentilus Holdco, LLC

Duke University

Sentilus, Inc.

Angus Hucknall

Ashutosh Chilkoti

Daniel Joh

Benjamin B Yellen

Michael S Hershfield

Aaron Franklin

Joseph Batton Andrews

Miriam Amiram

Yizhi Qi

Nancy J Ganson

Roozbeh Abedini-Nassab

Srinath Rangarajan

Disclosed herein are compositions and methods for reducing the antigenicity of molecules. The antigenicity of a molecule may be reduced or eliminated by conjugating at least one branched polymer to the molecule to form a molecule-polymer conjugate. The branched polymer may include a backbone and a plurality of side chains, each side chain covalently attached to the backbone.

Surfaces having reduced non-specific binding and antigenicity

Disclosed are sensors that include a carbon nanotube channel and a non-fouling polymer layer, where the non-fouling polymer layer and the carbon nanotube channel do not directly contact each other and are separated by a dielectric layer. The disclosed sensors may be used, e.g., as biosensors for the accurate and sensitive detection of analytes within a sample. Also disclosed are methods of making and using the sensors.

Nonfouling biosensors

Disclosed are devices and methods for detecting analytes from a sample.

Detection devices and related methods of use

Disclosed herein are chips, devices, methods of making the same, and methods of detecting a target analyte, and methods of diagnosing an individual with a disease or condition when a target analyte associated with the disease or condition is detected.

Chips, detectors, and methods of making and using the same

Disclosed herein are methods of detecting a target RNA, methods of diagnosing an individual with a disease or condition when a target RNA associated with the disease or condition is detected, and methods of conveying via a communication medium data from the detection of a target RNA.

Direct detection of RNA by surface initiated enzymatic polymerization

An article such as a biomolecular detector or biosensor having a nonfouling surface thereon includes: (a) a substrate having a surface portion; (b) a linking layer on the surface portion; and (c) a polymer layer formed on the linking layer; and (d) a first member of a specific binding pair (e.g., a protein, peptide, antibody, nucleic acid, etc.) bound to the polymer layer. Methods of making and using the articles are also described.

Growing community of inventors

Durham, NC, United States of America

Angus Hucknall