University of California

Anguraj Sadanandam

Joe W Gray

William J Gibb

Paul T Spellman

Wen-lin Kuo

Laura M Heiser

Nicholas J Wang

Herein is described the use of a collection of 50 breast cancer cell lines to match responses to 77 conventional and experimental therapeutic agents with transcriptional, proteomic and genomic subtypes found in primary tumors. Almost all compounds produced strong differential responses across the cell lines produced responses that were associated with transcriptional and proteomic subtypes and produced responses that were associated with recurrent genome copy number abnormalities. These associations can now be incorporated into clinical trials that test subtype markers and clinical responses simultaneously.

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Pollachi, India

Anguraj Sadanandam