Teva Pharmaceutical Fine Chemicals S.r.l.

Alfa Chemicals Italiana S.p.a.

Angelo Spreafico

Judith Aronhime

Stefano Bianchi

Paola Daverio

Adrienne Kovacsne-Mezei

Silvia Mantovani

Valeriano Merli

Vincenzo Cannata

Barbara Galbiati

The invention is directed to levalbuterol HCl Form B and methods of making the same.

Levalbuterol hydrochloride polymorph B

The invention is directed to processes for making levalbuterol HCl Polymorph A from by suspending or forming a first slurry of (R)-SLB(D)-DBTA in at least a first organic solvent, adding HCl to the suspension or slurry of the solid (R)-SLB.D-DBTA until the (R)-SLB.D-DBTA forms levalbuterol HCl Polymorph A, and isolating the levalbuterol HCl Polymorph A.

Levalbuterol hydrochloride Polymorph A

A process for manufacturing 1-(3-trifluoromethyl)phenyl-propan-2-one intermediate in the synthesis of the anorexic drug fenfluramine consists of reacting the diazonium salt of 3-trifluoromethylaniline with isopropenyl acetate in a polar solvent in the presence of a catalytic amount of a cuprous salt and, optionally, of a base and purifying the crude product through the bisulfite complex or distillation under vacuum.

Process for manufacturing 1-(3-trifluoromethyl)-phenyl-propan-2-one

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Lecco, Italy

Angelo Spreafico