The United States of America As Represented by the Department of Health

The United States of America, As Represented by the Secretary, Department of Health and Human Services

Louisiana State University and Agricultural & Mechanical College

Angelo Russo

James B Mitchell

David A Wink

Murali C Krishna

James E Liebmann

Murali Krishna Cherukuri

Sankaran Subramanian

Frank S Harrington

Rolf G Tschudin

Nallathamby Devasahayam

Ramachandran Murugesan

John A Cook

Ingeborg Hanbauer

Mobae Afeworki

Anne Marie DeLuca

Daniel Neil Granger

Matthew B Grisham

The present invention provides a method for the prophylactic and therapeutic treatment of cancer. The method comprises administering to an animal, preferably a mammal, more preferably a human, at risk for developing a cancer or having a cancer a nitroxide or a prodrug thereof, wherein the nitroxide or prodrug thereof preferably is alicyclic or heterocyclic and more preferably is a compound of Formula (I) or Formula (II): in an amount sufficient to prevent or treat said cancer, wherein said cancer is susceptible to prevention or treatment by said nitroxide or prodrug thereof. Also provided is a composition for use in the method 

Use of tempol for the treatment of Li-Fraumeni syndrome and ataxia telangiectasia

A radiofrequency (RF) coil design, suitable for detecting time domain electron paramagnetic resonance (EPR) responses from spin probes after pulsed excitation using radiofrequency irradiation (60-400 MHz), is configured in an array of numerous surface coils of appropriate diameters connected in a parallel or axial configuration with appropriate spacing between individual surface coils to form a volume type resonator.

Resonant structure for spatial and spectral-spatial imaging of free radical spin probes using radiofrequency time domain electron paramagnetic resonance spectroscopy

The present invention provides a method for sensitizing hypoxic cells in a tumor to radiation, wherein nitric oxide is delivered to target hypoxic cells through the administration of a nitric oxide-containing compound that spontaneously releases nitric oxide under physiological conditions without requiring the presence of oxygen. Also provided are methods of protecting noncancerous cells or tissues in a mammal from radiation, sensitizing cancerous cells in a mammal to chemotherapeutic agents, and protecting noncancerous cells or tissues in a mammal from chemotherapeutic agents, all by administration of the same compounds.

Use of nitric oxide releasing compounds to protect noncancerous cells

Nitric oxide-releasing compounds to sensitive cancerous cells to

Use of nitric oxide-releasing compounds as hypoxic cell radiation

The present invention provides a method for treating oxygen free radical induced tissue damage associated with ischemia reperfusion injury, wherein nitric oxide is delivered to target cells/tissues through the administration of a nitric oxide-containing compound that spontaneously releases nitric oxide under physiological conditions without requiring the presence of oxygen.

Nitric oxide releasing compounds as protective agents in ischemia

Use of nitric oxide releasing compounds as hypoxic cell radiation

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Bethesda, MD, United States of America

Angelo Russo