Incyte Pharmaceuticals, Inc.

Incyte Corporation

Angelo M Delegeane

Scott Michael Braxton

Dinh Diep

Janice K Au-Young

Y Tom Tang

Jennifer L Hillman

Olga Bandman

Preeti G Lal

Purvi Shah

Surya K Goli

Henry Yue

Phillip R Hawkins

Mariah R Baughn

Jeffrey J Seilhamer

Lynn E Murry

Ingrid E Akerblom

Ernestine A Lee

Dyung Aina M Lu

April J A Hafalia

Monique G Yao

Ameena R Gandhi

Chandra S Arvizu

Yan Lu

Neil Burford

Tod M Klingler

Danniel B Nguyen

Li Ding

Bridget A Warren

Junming Yang

Roopa M Reddy

Vicki S Elliott

Narinder K Chawla

Rajagopal Gururajan

Brendan M Duggan

Richard D Goold

Catherine M Tribouley

Jayalaxmi Ramkumar

Farrah A Khan

Liam Kearney

Christina M Altus

Debopriya Das

Stephen Todd

Deborah A Kallick

Mark L Borowsky

Roberto Hernandez

Steve E Lincoln

Wendy B Levine

Samuel T LaBrie

The invention provides a human cysteine proteases and polynucleotides which encode those proteases. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists, as well as methods for diagnosing, treating, or preventing disorders associated with aberrant expression of cysteine proteases.

Proteases

The present invention is a computerized storage and retrieval system for genetic information and related annotated information. The data of the system is stored in a relational database which interfaces with public databases to allow analysis both within the database of the invention and between information within that database and external public databases. The sequence data is edited before entry into the system, and is stored in a curated, functional clustering organization. The information associated with the data is stored in an expression database that is linked to the storage of the sequence data.

Database for storage and analysis of full-length sequences

The present invention provides nucleotide and amino acid sequences that identify and encode a human homolog of rat elastase IV (HEIV) expressed in pancreas tissue. The present invention also provides for antisense molecules to the nucleotide sequences which encode HEIV, hybridization probes or oligonucleotides for the detection of HEIV-encoding nucleotide sequences, and a diagnostic test based on HEIV-encoding nucleic acid molecules. The present invention further provides for genetically engineered host cells for the expression of HEIV, biologically active HEIV, antibodies capable for binding specifically to HEIV, and treatment methods comprising administration of compounds, such antibodies or inhibitors, capable of binding HEIV to alter its activity.

Antibody for a homolog of rat elastase IV derived from human pancreas

The present invention provides a polynucleotide (ncp) which identifies and encodes a novel cysteine protease (NCP) expressed in cells of both the adrenal gland and human umbilical vein endothelium. The present invention also provides for antisense molecules and oligomers designed from the nucleotide sequence or its antisense. The invention further provides genetically engineered expression vectors and host cells for the production of purified NCP peptide, antibodies capable of binding to NCP, inhibitors which bind to NCP and pharmaceutical compositions based on NCP specific antibodies or inhibitors. The invention specifically provides for diagnostic assays based on altered ncp expression and which allow identification of such a condition. These assays utilize probes designed from ncp encoding or controlling nucleic acid sequences or antibodies specific for the NCP.

Human cysteine protease

Homolog of rat elastase IV derived from human pancreas

DNA encoding human cysteine protease

The present invention provides nucleotide and amino acid sequences that identify and encode a new human interleukin-1 converting enzyme homolog (ICEY). The present invention also provides for antisense molecules to the nucleotide sequences which encode ICEY, expression vectors for the production of purified ICEY, antibodies capable of binding specifically to ICEY, hybridization probes or oligonucleotides for the detection of ICEY-encoding nucleotide sequences, genetically engineered host cells for the expression of ICEY, diagnostic tests for activation of monocyte/macrophages based on ICEY-encoding nucleic acid molecules, and use of the protein to produce antibodies capable of binding specifically to the protein and use of the protein to screen for inhibitors.

Human ice homolog antibodies and compositions thereof

Method of detecting elastase IV

The present invention provides nucleotide and amino acid sequences that identify and encode a new human interleukin-1 converting enzyme homolog (ICEY). The present invention also provides for expression vectors for the production of purified ICEY, hybridization probes for the detection of ICEY-encoding nucleotide sequences, genetically engineered host cells for the expression of ICEY, diagnostic tests for ICEY or for polynucleotides encoding ICEY, and use of the protein to produce antibodies capable of binding specifically to the protein and use of the protein to screen for inhibitors.

Human ice homolog

Growing community of inventors

Hayward, CA, United States of America

Angelo M Delegeane