Ethicon, Gmbh

Wyeth

Cordis Corporation

Ethicon, Inc. - USA

Angelo G Scopelianos

Mark B Roller

Rao S Bezwada

Steven C Arnold

Murty Narayan Vyakarnam

David V Gorky

Mark C Zimmerman

David Christian Lentz

Eugene P Reilly

Clairene A Bazilio

Dennis D Jamiolkowski

Robert J Tannhauser

Anna Gosiewska

Kevin L Cooper

Gerard H Llanos

Shawn Thayer Huxel

Iksoo Chun

Mora Carolynne Melican

Pallassana V Narayanan

Chao C Chen

Robert Falotico

Alireza Rezania

Kevin Shaun Weadock

Yufu Li

Agnieszka Seyda

James H Silver

Luis A Davila

Zhigang Li

David C Colter

Charito S Buensuceso

Jeffrey C Geesin

Kelly R Brown

David J Wilson

David Wasserman

David A Dalessandro

John McAllen, Iii

John J Spaltro

Alan Roy Pelton

Stephen C Arnold

William D Shaw, Jr

Jorge Orlando Mendez

Karl K Scheidt

Christine Trepanier

Richard D Gooding

William Douglas Shaw, Jr

David C Lentz

Dhanaraj Sridevi

Jorge O Mendez

Alan R Pelton

Medical devices, and in particular implantable medical devices, may be coated to minimize or substantially eliminate a biological organism's reaction to the introduction of the medical device to the organism. The medical devices may be coated with any number of biocompatible materials. Therapeutic drugs, agents or compounds may be mixed with the biocompatible materials and affixed to at least a portion of the medical device. These therapeutic drugs, agents or compounds may also further reduce a biological organism's reaction to the introduction of the medical device to the organism. Various materials and coating methodologies may be utilized to maintain the drugs, agents or compounds on the medical device until delivered and positioned.

Coated medical devices

Medical devices, drug coatings and methods for maintaining the drug coatings thereon

The present patent describes a biocompatible composite made of a first fibrous layer attached to a three-dimensional inter-connected open cell porous foams that have a gradient in composition and/or microstructure through one or more directions. These composites can be made from blends of absorbable and biocompatible polymers. These biocompatible composites are particularly well suited to tissue engineering applications and can be designed to mimic tissue transition or interface zones.

Foam composite for the repair or regeneration of tissue

The present invention includes biocompatible coatings and films for use on implantable medical devices and medical devices containing such coatings and films applied to a surface thereof, which coatings/films are present on the device in an amount effective to provide an inert surface to be in contact with body tissue of a mammal upon implantation of the device in the mammal, and contain a film-forming polyfluoro copolymer containing the polymerized residue of a moiety selected from the group consisting of vinylidenefluoride and tetrafluoroethylene copolymerized with a second moiety other than the first moiety, wherein the relative amounts of the polymerized residue of the first and second moieties are effective to provide the coating and films with properties effective for use in coating implantable med devices.

Coatings for medical devices

A biocompatible tissue implant, as well as methods for making and using such an implant, is provided. Preferably, the tissue implant is bioabsorbable. The tissue implant comprises one or more layers of a bioabsorbable polymeric foam having pores with an open cell structure. The tissue implant also includes a reinforcement component which contributes both to the mechanical and the handling properties of the implant. Preferably, the reinforcement component is bioabsorbable as well. The tissue implant provided can be used in connection with the surgical repair of soft tissue injury, such as injury to the pelvic floor.

Reinforced tissue implants and methods of manufacture and use

The present patent describes a three-dimensional inter-connected open cell porous foams that have a gradient in composition and/or microstructure through one or more directions. These foams can be made from a blend of absorbable and biocompatible polymers that are formed into foams having a compositional gradient transitioning from predominately one polymeric material to predominately a second polymeric material. These gradient foams are particularly well suited to tissue engineering applications and can be designed to mimic tissue transition or interface zones.

Porous tissue scaffoldings for the repair or regeneration of tissue

The present patent describes a three-dimensional interconnected open cell porous foams that have a gradient in composition and/or microstructure through one or more directions. These foams can be made from a blend of absorbable and biocompatible polymers that are formed into foams having a compositional gradient transitioning from predominately one polymeric material to predominately a second polymeric material. These gradient foams are particularly well suited to tissue engineering applications and can be designed to mimic tissue transition or interface zones.

The present invention provides an improved lyophilization process for forming biocompatible foam structures. The process allows the foam structures to be tailored for specific end uses. The foams formed by this process are well suited to be used in medical applications such as tissue engineering. The foam structures may also contain pharmaceutically active substances

Process for manufacturing biomedical foams

The present invention provides surgical article and suture coated with bioabsorbable microdispersions which contains a fluid carrier that is a liquid polymer and a particular material.

Microdispersions for coating surgical devices

Porous tissue scaffoldings for the repair of regeneration of tissue

The present claims are directed to a tipped surgical suture and a solventless method for making a tipped suture comprising a suture coated with 6-30 weight percent, based on the total weight of the tipped region of the suture, of a bioresorbable aliphatic polyester copolymer which itself comprises from 70-100 mole % of e-caprolactone repeating units or from 80-100 mole % of trimethylene carbonate repeating units, the remainder of repeating units in the copolymer comprising a plurality of lactide, 1,4-dioxan-2-one, 1,4-dioxepan-2-one units.

Solventless tipping of braided surgical ligature

The present invention provides injectable, bioabsorbable liquid copolymers suitable for use as a soft tissue repair or augmentation material in animals comprising a liquid polymer selected from the group consisting of liquid polymers of a plurality of at least two different first lactone repeating units and liquid polymers of a plurality of first lactone and second lactone repeating units; wherein the first lactone repeating units are selected from the group consisting of .epsilon.-caprolactone repeating units, trimethylene carbonate repeating units, ether lactone repeating units (which for the purpose of this invention shall mean 1,4-dioxepan-2-one and 1,5-dioxepan-2-one) and combinations thereof and the second lactone repeating units are selected from the group consisting of glycolide repeating units, lactide repeating units (which for the purpose of this invention are defined to be L-lactide, D-lactide, or D,L-lactide repeating units), p-dioxanone repeating units and combinations thereof. Additionally, the present invention also discloses methods of using these liquid copolymers for tissue augmentation and repair as well as kits which include prefilled containers to facilitate the use of these materials.

Injectable liquid copolymers for soft tissue repair and augmentation

Absorbable/resorbable mixtures of aliphatic polyesters of poly(lactide), poly(glycolide), poly(trimethylene carbonate), poly(p-dioxanone) and poly(.epsilon.-caprolactone) and calcium containing bone regenerating compounds such as powdered, non-fibrous calcium phosphates are described. The composites when used to manufacture medical devices exhibit improved absorption characteristics and other physical properties.

Hard tissue bone cements and substitutes

Growing community of inventors

Whitehouse Station, NJ, United States of America

Angelo G Scopelianos