Zambon S.p.a.

Zambon Group S.p.a.

Angelo Carenzi

Dario Chiarino

Davide Della Bella

Franco Pellacini

Viviana Frigeni

Mario Fantucci

Franco Pozzi

Gian Carlo Grancini

Giancarlo Grancini

Carlo Veneziani

Antonio Longo

Mauro Napoletano

Alberto Sala

Vittorio Ferrari

Mario Portelli

Sante Ricciardi

Alberto Pilotto

Vittorio Ferrrari

Claudia Tortora

Giancarlo Benelli

Gianni Pezzoli

Described are pharmaceutical compositions containing neurotrophically effective amount of Epidermal Growth Factor (EGF) as active ingredient together with pharmaceutical excipients and their use in the method of treatment of neurodegenerative disorders, such as Parkinsonism and disorders of traumatic origin.

Method of treating neurodegenerative disorders using epidermal growth

A diastereoselective process for the preparation of compounds of formula ##STR1## (wherein R and R.sub.1 have the meanings reported in the specification and the asterisks show the asymmetric carbon atoms) starting from the corresponding N-protected 2-amino-3-aryl-propan-1-ol is described. The compounds of formula I are intermediates useful for the synthesis of pharmacologically active peptides.

Diastereoselective process for the preparation of intermediates useful

Compounds of the formula ##STR1## wherein R, R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5 and n have the meanings reported in the specification, processes for their preparation and pharmaceutical compositions containing them as active ingredient are described. The compounds of formula I are inhibitor of enzymatic systems and they are useful in pharmaceutical field.

Peptides with pharmaceutical activity

The blood level of orally administered N-acetylcysteine is substantially increased in a mammal when the N-acetylcysteine is administered in combination with tris(hydroxymethyl)aminomethane or a pharmaceutically acceptable salt thereof, in a molar ratio of about 1:0.8 to about l:l.2.

Method and composition for oral administration of N-acetylcysteine

Compounds of formula ##STR1## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, and n have the meanings reported in the specification, processes for their preparation and pharmaceutical compositions containing them as active ingredient are described. The compounds of formula I are inhibitors of enzymatic systems and they are useful in pharmaceutical field.

Compounds of formula ##STR1## (wherein R, R.sub.1, R.sub.2 and Y have the meanings indicated in the description), a process for the preparation thereof and pharmaceutical compositions containing them as active ingredient are described. Compounds of formula I exhibit anto-serotonin activity.

Isoxazole containing compounds exhibiting anti-serotonin activity

Isoxazoles with nootropic activity

The cap reservoir and dropper assembly for bottles includes a reservoir (1) fitted with a collar 913) adapted for resting on the mouth of a bottle (4), a delivery piston (2) the lower part of which is shaped like a flute mouthpiece (24) and the upper part of which is shaped like a collar (22). The assembly further includes a cap (3) the lower part of which is in the form of a removable strip (33). The delivery piston is equipped in its upper part with a dropper (23). The cap may be equipped with a feature which cooperates with the delivery piston collar to push the delivery piston downwards.

Cap, reservoir and dropper assembly for bottles

Compounds of formula ##STR1## (wherein R, R.sub.1, R.sub.2, R.sub.3 and n have the meanings reported in the specification), their salts with pharmaceutically acceptable acids, process for their preparation and pharmaceutical compositions containing them are described. The compounds of formula I have a remarkable analgesic activity.

Pyrrolidone-2 compounds and their use for central analgesic activity

Compounds of the formula ##STR1## wherien R, R.sub.1, R.sub.2 and Y have the meanings mentioned in the description, processes for their preparation and their use in the pharmaceutical field are described. The compounds of formula I are endowed with antipyretic, anti-inflammatory, mucolitic and analgesic activity together with good gastric tolerability. In addition, the compounds of formula I are active in the treatment of ischemic or reperfusion syndromes.

Derivatives of thiazolidine-4-carboxylic acid having pharmacological

Pharmaceutical preparations for veterinary use, in the form of concentrate solutions, containing Thiamphenicol as active ingredient are described. Such pharmaceutical preparations with antibiotic activity have the following compositions:

Pharmaceutical preparation containing thiamphenicol for veterinary use

Compounds of formula ##STR1## (wherein R, R.sub.1 and R.sub.2 have the meanings reported in the specification) and their preparation are described. The compounds of formula I have anti-allergic, anti-anaphylactic and anti-arthritic activity and are useful in pharmaceutical field. Compositions for pharmaceutical use containing a compound of formula I as active ingredient are described too.

4-(3-Coumarinyl)-thiazole-derivatives with anti-allergic,

Pharamaceutical composition containing ubidecarenone

Compounds of formula ##STR1## in which R, R.sub.1 and Y have the meanings shown in the description, their preparation by condensing an aldehyde or a ketone with cysteine or a derivative thereof and their use in the pharmaceutical field. The compounds of formula I possess antipyretic, anti-inflammatory, mucolytic and analgesic activity together with a low capacity to cause gastric injuries. The compounds of formula I, furthermore, are particularly useful in the treatment of ischemia and reperfusion syndromes.

Pharmaceutically useful derivatives of thiazolidine-4-carboxylic acid

Compounds of formula ##STR1## (wherein R and R.sub.1 have the meanings reported in the specification) and their preparation are described. The compounds of formula I have anti-allergic, anti-anaphylactic and anti-arthritic activity and are useful in pharmaceutical field. Compositions for pharmaceutical use containing a compound of formula I as active ingredient are described too.

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Busto Arsizio, Italy

Angelo Carenzi