Ustav Experimentalni Botaniky Av Cr, V.v.i.

Palacky University Olomouc

Angelika Vollmar

Miroslav Strnad

Vladimir Krystof

Libor Havlicek

Antonin Sturc

Radek Jorda

Tomas Pospisil

Stefan Zahler

5-substituted-7-[4-(2-pyridyl)phenylmethylamino]-3-isopropylpyrazolo[4,3-d]pyrimidines are potent inhibitors of protein kinases, especially cyclin-dependent kinases such as CDK2 and CDK5, and display antileukemic, pro-apoptotic, antiangiogenic and anticancer activities. The invention also relates to processes for their preparation, to pharmaceutical compositions and to their use as medicaments, particularly in the treatment of disorders involving cell proliferation, apoptosis, angiogenesis and inflammation, such as leukemia and metastatic solid cancer.

5-substituted 7- [4-(2-pyridyl)phenylmethylamino] -3-isopropylpyrazolo4,3-D]pyrimidine derivatives, use thereof as medicaments, and pharmaceutical compositions

Growing community of inventors

Pullach, Germany

Angelika Vollmar