Roche Diagnostics Gmbh

Boehringer Mannheim Gmbh

Other

Angelika Esswein

Christos Tsaklakidis

Elmar Bosies

Lothar Kling

Frieder Bauss

Walter-Gunar Friebe

Ernesto Menta

Hans-Willi Krell

Gerd Zimmermann

Frank Grams

Wolfgang Schaefer

Klaus Kaluza

Konrad Honold

Ulrike Leser

Liesel Dorge

Wolfgang Schafer

Eike Hoffmann

Silvia Konetschny-Rapp

The invention is directed to compounds of formula (I) wherein Ralkyl, alkenyl or alkynyl having from 6 to 24 carbon atoms; n=0-12; X=oxygen or NH; and the physiologically safe salts, esters, optically active forms, racemates and derivatives thereof which can be metabolized in vivo to yield compounds of general formula (I), methods of preparing same, and drugs containing said compounds, for treating bone metabolic disorders.

Osteoblast-specific mitogens and drugs containing such compounds

Compounds of general formula (I), in which m is 0-8, q is a 0-8, a is 0-4, A signifies a single or double bond, R , R signify hydrogen or lower alkyl and, when m signifies 2-8, R and R in the group CR &boxH;CR can have various significances within the following sequence, R signifies hydrogen or lower alkyl, X signifies hydrogen or &mdash;(CH ) &mdash;COR with b&equals;0-4, Y signifies hydrogen, &mdash;COR , phenyl or indolyl residue R signifies hydroxyl, lower alkoxy or the NR R residue, W signifies an optionally mono- or polysubstituted saturated or unsaturated mono-, bi- or tricycle which can contain hetero atoms, as well physiologically compatible salts, esters, optically active forms, racemates, tautomers, and derivatives which can be metabolized in vivo to compounds of general formula (I).

Rhodanine carboxylic acid derivatives for the treatment and prevention of metabolic bone disorders

Barbituric acid derivatives, processes for their production and pharmaceutical agents containing these compounds

Amino alcohol derivatives, method of producing said derivatives and medicaments containing them

Arginine mimetic peptides according to Formula I of this application have a stimulating effect on bone formation and are useful for the treatment of bone metabolic disorders.

Peptides containing an arginine mimetic for the treatment of bone metabolic disorders, their production, and drugs containing these compounds

Osteoblast-specific mitogens and drugs containing such compounds can be used for treating metabolic bone diseases. These compounds include lysophosphatidylic acid derivatives selected from the group consisting of compounds of formula:

Barbituric acid derivatives, processes for their production and

The present invention concerns new oxazolidinone derivatives, processes for their production as well as pharmaceutical agents containing these substances. The present invention concerns compounds of the general formula I ##STR1## in which the symbols have the meanings as listed in the claims.

Oxazolidinone derivatives, processes for the production thereof and

2,4-diphosphonoglutaric acid derivatives, processes for their production

Phosphosuccinic acid derivatives, processes for the production thereof

Compounds of the formula I ##STR1## in which R signifies a possibly substituted amino group of the general formula --NR.sup.1 R.sup.2, whereby, independently of one another, R.sup.1 and R.sup.2 each signify hydrogen, lower alkyl, lower alkenyl or lower alkynyl or R represents a saturated, unsaturated or aromatic heterocyclic ring which can possibly be substituted once or twice by lower alkyl or halogen, alk signifies a valency bond, a methylene, a saturated or unsaturated, straight-chained or branched alkylene chain with 2-6 carbon atoms and R.sup.3, R.sup.4 and R.sup.5, in each case independently of one another, signify hydrogen, lower alkyl or benzyl, as well as their pharmacologically acceptable salts and enantiomers, whereby, for the case that R.sup.3 =R.sup.4 =R.sup.5 =CH.sub.3 and alk signifies a valency bond, R cannot be the dimethylamino group, processes for their preparation and medicaments which contain these compounds for the treatment of calcium metabolism diseases.

Phosphonic acid compound containing heterocyclic substituents,

Phosphonosuccinic acid derivatives, processes for their preparation and

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Singen, Germany

Angelika Esswein