Inhibrx Biosciences, Inc.

Inhibrx, Inc.

Regeneron Pharmaceuticals, Inc.

Angelica N Sanabria

Brendan P Eckelman

John C Timmer

Rajay A Pandit

Lucas Rascon

William Crago

Andrew Hollands

Florian Sulzmaier

Milton Ma

Jacob Gano

Jordan Jarjour

Kyle S Jones

Katelyn M Willis

Mark Pogson

Wai-hang Leung

Michael D Kaplan

Margaret E Haerr

Sydney A Barnes

The present disclosure provides improved CLL-1 targeting polypeptides and compositions for adoptive T cell therapies for treating, preventing, or ameliorating at least one symptom of a cancer, infectious disease, autoimmune disease, inflammatory disease, and immunodeficiency, or condition associated therewith.

CLL-1 targeted immunotherapies

Provided herein are binding polypeptides that specifically bind DLL3. More specifically, provided herein are fusion proteins, including multivalent and/or multispecific contracts and chimeric antigen receptors, that bind DLL3. Also provided are pharmaceutical compositions containing the polypeptides, nucleic acid molecules encoding the polypeptides and vectors and cells thereof, and methods of use and uses of the provided DLL3 binding polypeptides for treating diseases and conditions, such as cancer.

DLL3 single domain antibodies and therapeutic compositions thereof

Provided herein are binding polypeptides that specifically bind PD-1. More specifically, provided herein are fusion proteins, including multivalent and/or multispecific constructs and chimeric antigen receptors, that bind PD-1. Also provided are pharmaceutical compositions containing the polypeptides, nucleic acid molecules encoding the polypeptides and vectors and cells thereof, and methods of use and uses of the provided PD-1 binding polypeptides for treating diseases and conditions, such as cancer.

PD-1 single domain antibodies and therapeutic compositions thereof

Provided herein are VHH-containing polypeptides that bind CD33. Uses of the VHH-containing polypeptides are also provided.

CD33-binding polypeptides and uses thereof

Provided herein are VHH-containing polypeptides that bind CLEC12a. Uses of the VHH-containing polypeptides are also provided.

CLEC12a binding polypeptides and uses thereof

Growing community of inventors

La Jolla, CA, United States of America

Angelica N Sanabria