Vaccinex, Inc.

Angelica A Cornelison

Ernest S Smith

Mark Paris

Renee A Kirk

Maria G M Scrivens

Maurice Zauderer

Tracy Pandina

Leslie A Balch

Maria Scrivens

Compositions and method are provided for treating diseases associated with semaphorin-4D (SEMA4D) pathology, including autoimmune diseases, inflammatory diseases, cancers, neuroinflammatory disorders and neurodegenerative diseases.

Human anti-semaphorin 4D antibody

This disclosure provides compositions and methods for expressing and displaying isolated integral membrane proteins (IMPs) or fragments thereof in a native conformation for use in the screening, selecting, and identifying of antibodies or antibody-like molecules that bind to a target IMP of interest.

Integral membrane protein display on poxvirus extracellular enveloped virions

The present invention relates to a high efficiency method of expressing immunoglobulin molecules in eukaryotic cells. The invention is further drawn to a method of producing immunoglobulin heavy and light chain libraries, particularly using the trimolecular recombination method, for expression in eukaryotic cells. The invention further provides methods of selecting and screening for antigen-specific immunoglobulin molecules, and antigen-specific fragments thereof. The invention also provides kits for producing, screening and selecting antigen-specific immunoglobulin molecules. Finally, the invention provides immunoglobulin molecules, and antigen-specific fragments thereof, produced by the methods provided herein.

Method for selecting polynucleotides encoding antigen-specific immunoglobulin subunit

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Pittsford, NY, United States of America

Angelica A Cornelison