The University of British Columbia

Xenon Pharmaceuticals Inc.

Wisconsin Alumni Research Foundation

Xenon Genetics Inc.

The Public Health Agency of Canada

Angela R Brooks-Wilson

Michael R Hayden

Simon N Pimstone

Steven J Jones

Mark Eric Cook

Alan D Attie

Robert A Holt

Robert C Brunham

Mark Gray-Keller

Heinz Feldmann

Rachel Roper

Christopher Upton

Frank Plummer

Yan Li

Nathalie Bastien

Caroline Astell

The invention features ABC1 nucleic acids and polypeptides for the diagnosis and treatment of abnormal cholesterol regulation. The invention also features methods for identifying compounds for modulating cholesterol levels in an animal (e.g., a human).

Polynucleotide encoding an ATP binding cassette transporter 1 (ABC1) polypeptide

The invention provides, in part, the genomic sequence of a putative coronavirus, the SARS virus, and provides novel nucleic acid and amino acid sequences that may be used, for example, for the diagnosis, prophylaxis, or therapy of a variety of SARS virus related disorders.

SARS virus nucleotide and amino acid sequences and uses thereof

Methods and reagents for modulating cholesterol levels

Methods and compounds are disclosed for lowering serum LDL levels or serum cholesterol levels, or for reducing the transport of cholesterol from the gut to the blood or the lymph, based on the observation that a gene known as ABC1 is necessary in order for cholesterol to be transported from the intestinal lumen into the bloodstream. A mutant chicken phenotype, known as the WHAM chicken, characterized by low levels of serum LDL and reduced transport of cholesterol, facilitated the discovery of this function of the ABC1 gene. Techniques which act to inhibit ABC1 activity in the cells of the intestinal wall will result in lower serum cholesterol.

Cholesterol transport gene

Growing community of inventors

Richmond, CA, United States of America

Angela R Brooks-Wilson