Massachusetts Institute of Technology

The University of Texas System

Harvard College

Siluria Technologies, Inc.

Angela M Belcher

Ki Tae Nam

Chuanbin Mao

Daniel J Solis

Paula T Hammond

Jifa Qi

Beau R Peelle

Xiangnan Dang

Uyanga Tsedev

Neelkanth M Bardhan

Hyunjung Yi

Zhongming Li

David A Weitz

Jin-Woong Kim

Xina Quan

Eric Krauland

Evelyn Lynn Hu

Paula T Hammond-Cunningham

Nurxat Nuraje

Daeyeon Lee

Chung-Yi Chiang

Stephen Kottmann

Roberto Juan Barbero

Yu Lei

Yoon Sung Nam

Andrew Parsons Magyar

Brian D Reiss

Brian Neltner

Matthew T Klug

Fred Lam

George Le-Le Sun

Michael S Strano

Karl Dane Wittrup

Jeffrey C Grossman

Christopher A Voigt

Hash Pakbaz

Pil Jin Yoo

Soo-Kwan Lee

Andrew M Siegel

Paiman Peter Ghoroghchian

Nandini Rajan

Juhyun Park

Ruogu Qi

Zhimin Tao

Erik Mark Krauland

Priyank Vijaya Kumar

Hiroshi Atsumi

Xunpei Liu

Asher K Sinensky

Dong Soo Yun

Kiley P H Miller

Archit Sanghvi

Seung-Wuk Lee

Geran Zhang

Debadyuti Ghosh

Christine J Schmidt

Tae-Gon Cha

Noemie-Manuelle Dorval Courchesne

Po-Yen Chen

Evelyn Hu

An engineered phage-derived particle (PDP) for expressing a transgene in a target cell transduced with a bacteriophage, the PDP includes (i) less than about 500 bp of DNA from the bacteriophage genome, (ii) an ITR-flanked therapeutic gene up to 20 kb, (iii) an endosomal escape sequence, (iv) a nuclear localization sequence, and (v) a cell-specific targeting moiety. The PDP may escape lysosomal degradation, traffic across the nuclear envelope and expressed a therapeutic gene in a mammalian cell.

M13 phage based gene therapy platform

This disclosure provides a method for imaging lymph nodes and lymphatic vessels without a contrast agent. The method includes providing, using an optical source, an infrared illumination to a region of a subject having at least one lymphatic component, detecting a reflected portion of the infrared illumination directly reflected from the region using a sensor positioned thereabout, and generating at least one image indicative of the at least one lymphatic component in the subject using the reflected portion of the infrared illumination.

Systems and methods for lymph node and vessel imaging

Provided herein, in some aspects, are methods and compositions for producing single-stranded DNA (ssDNA) having uniform length.

Optimization of circular single stranded DNA using M13 phage

Provided are engineered phages populations, which are homogeneous in length, as well as methods of making and methods of using such phages. Also provided are engineered chlorotoxin-phages as well as their methods of making and using. The disclosed homogeneous phage populations and chlorotoxin-phages may be used, for example, for treating and/or imaging tumors, such as central nervous system tumors.

Homogeneous engineered phage populations

Metal bioremediation and metal mining strategies can include compositions and methods.

Engineered yeast as a method for bioremediation

A composition can include a carbon nanofiber, wherein a precursor for the carbon nanofiber includes an alcohol and an aldehyde crosslinked by a primary amine. In certain embodiments, the carbon nanofiber can be biotemplated. Biotemplating enables precise control of morphology at the nanometer scale, while molecular templating allows control of carbon nanotexture and structure at the sub-nanometer scale.

Microporous carbon nanofibers

Disclosed are methods of treating cancer of the intraperitoneal cavity using compositions comprising nanoparticles without targeting agents. In addition, nanoparticles are described that comprise a highly toxic anticancer agent (e.g., an anticancer agent having an ICless than 1 nM) covalently bound via a linker to a triblock copolymer. Other nanoparticles that comprise Pt(IV) and an anticancer agent are also described. Also disclosed are nanoparticles comprising imaging agents non-covalently associated with a polymer, and methods of imaging cancer of the intraperitoneal cavity using compositions comprising nanoparticles without targeting agents.

Nanoparticle conjugates of highly potent toxins and intraperitoneal administration of nanoparticles for treating or imaging cancer

System and method configured to operate under conditions when the object being imaged destroys or negates the information which otherwise allows the user to take advantage of optical parallax, configured to elicit luminescence from the same targets in the object as a result of irradiation of these targets with pump light at different, respectively corresponding wavelengths, and acquire optical data from so-illuminated targets through the very same optical path to image the object at different wavelengths. One embodiment enables acquisition, by the same optical detector and from the same object, of imaging data that includes a reflectance image and multiple fluorescence-based images caused by light at different wavelengths, to assess difference in depths of locations of targets within the object.

Enhancement of video-rate fluorescence imagery collected in the second near-infrared optical window

A biotemplated nanomaterial can include a crystalline perovskite.

Biotemplated perovskite nanomaterials

To deliver surfactants or tracers to underground oil fields, inorganic encapsulated surfactant nanoparticles or microparticles that are stable for several weeks under high temperature and high salt conditions can be used.

Multifunctional particles for enhanced oil recovery

A dye-sensitized solar cell can include a plurality of a plasmon-forming nanostructures. The plasmon-forming nanostructures can include an oxide core, an inner metallic shell on a surface of the oxide core, and an outer oxide shell on a surface of the inner metallic shell.

Plasmon-enhanced dye-sensitized solar cells

Growing community of inventors

Lexington, MA, United States of America

Angela M Belcher