3m Innovative Properties Company

Massachusetts Institute of Technology

Angela K Dillow

Robert Samuel Langer

David S Hays

G Marco Bommarito

Patrick A Mach

Jeffrey S Hrkach

John S Huizinga

Brinda Balasubramaniam Lakshmi

Ryan B Prince

M Benton Free

John L Battiste

Dasaratha V Sridhar

Randall P Brown

Neil Foster

Benton M Free

The invention relates to methods of detecting

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Colorimetric sensors comprising a receptor incorporated within polydiacetylene assemblies to form a transducer capable of indicating a color change when contacted with an analyte are disclosed. Methods of using the colorimetric sensor and a kit for the colorimetric detection of an analyte are also disclosed.

Colorimetric sensors constructed of diacetylene materials

A method is provided for sterilizing materials, particularly polymers, for drug delivery and implantation, wherein the material is treated with supercritical fluid carbon dioxide at pressures in the range of 2000 to 3000 psi (140 to 210 bar) and temperatures preferably between 30 and 45.degree. C. for periods between 20 minutes and six hours, more preferably between 0.5 and 2 hours. Agitation, pressure cycling, and the presence of water were found to enhance the sterilization method, which promotes diffusion of the supercritical fluid carbon dioxide into the cells of the microorganism to thereby alter the pH within the cells, killing them. The magnitude and frequency of the pressure cycling, as well as the process time and temperature, may vary according to the type and form of the material to be sterilized and the type of organisms to be killed.

Supercritical fluid sterilization method

Growing community of inventors

Minneapolis, MN, United States of America

Angela K Dillow