Massachusetts Institute of Technology

Harvard College

The Broad Institute, Inc.

Angela Early

Feng Zhang

James Joseph Collins

Omar O Abudayyeh

Jonathan S Gootenberg

Eric Lander

Daniel Neafsey

The embodiments disclosed herein utilized RNA targeting effectors to provide a robust CRISPR-based diagnostic with attomolar sensitivity. Embodiments disclosed herein can detect broth DNA and RNA with comparable levels of sensitivity and can differentiate targets from non-targets based on single base pair differences. Moreover, the embodiments disclosed herein can be prepared in freeze-dried format for convenient distribution and point-of-care (POC) applications. Such embodiments are useful in multiple scenarios in human health including, for example, viral detection, bacterial strain typing, sensitive genotyping, and detection of disease-associated cell free DNA.

CRISPR effector system based diagnostics for malaria detection

Growing community of inventors

Cambridge, MA, United States of America

Angela Early