Dso 'Pharmachim'

Medizinska Akademia

Angel Simeonov Galabov

Dushka Staneva Stoycheva

Zlatka Petkova Dimcheva

Ragka Taneva Vassileva

Lubomir Mihaylov Shindarov

Emilia Hristova Velichkova

Georgi Nikolov Vassilev

Margarita H Mastikova

Interferon is produced in vivo or in vitro by administration of dipyridamole as interferon inducer to cellular material. Interferon may be induced in warm blooded animals by administration of dipyridamole orally in single doses of 1.0 to 100 mg/kg, intraperitoneally in single doses of 0.1 to 16.7 mg/kg and intravenously in an amount of 0.01 to 50 mg/kg.

Interferon induction method

A method of treating picorna viral infections, particularly of the picornaviruses, is provided which comprises treating the patient with an effective amount of a compound of the formula ##STR1## wherein R is hydrogen or methyl; and R' is lower alkyl, allyl, .beta.-hydroxyethyl, .beta.-aminoethyl, .omega.-aminohexyl, a fatty acid radical, methoxyphenyl, chlorophenyl, phenyl, benzyl, tolyl, hydroxyphenyl, carboxyphenyl, chinoyl, carboxyhydroxyphenyl, hydroxynitrophenyl, nitrophenyl, hydroxychlorophenyl, chloronitrophenyl, phenylthioureidohexyl, trimethylphenyl, methylchlorophenyl, pyridyl, acetylphenyl, acetylaminophenyl, dimethylaminophenyl, aminopyridyl, phenylthioureidopyridyl, phenylthioureidonaphtyl, aminonaphthyl, chlorophenylthioureidophenyl, furfuryl, dichlorophenyl or allylthioureidophenyl. The compound may be administered orally, preferably in dosages of from 40 to 200 mg per kilogram body weight.

Method for treating a picorna virus infection

Growing community of inventors

Sofia, Bulgaria

Angel Simeonov Galabov