Bristol-myers Squibb Compnay

Five Prime Therapeutics, Inc.

Andy X Deng

Paul O Sheppard

Alan J Korman

Mark J Selby

Guodong Chen

Brigitte Devaux

Michelle Minhua Han

Huiming Li

Ekaterina G Deyanova

Christine Bee

Xiao Min Schebye

Daniel F Ardourel

Anan Chuntharapai

Richard Y Huang

Michelle Renee Kuhne

Hong-An Truong

Arvind Rajpal

Ginger Chao Rakestraw

Keith Sadoon Bahjat

Andrew Rankin

Robert J Johnston

Lin Hui Su

Luis Borges

Richard Yu-Cheng Huang

Hong-An Troung

Michelle Kuhne

Provided herein are antibodies, or antigen-binding portions thereof, that bind to T-cell immunoglobulin and mucin-domain containing-3 (TIM3) protein. Also provided are uses of these antibodies, or antigen-binding portions thereof, in therapeutic applications, such as treatment of cancer. Further provided are cells that produce the antibodies, or antigen-binding portions thereof, polynucleotides encoding the heavy and/or light chain regions of the antibodies, or antigen-binding portions thereof, and vectors comprising the polynucleotides encoding the heavy and/or light chain regions of the antibodies, or antigen-binding portions thereof.

Antibodies against TIM3 and uses thereof

The present application relates to antibodies specifically binding to the V-domain immunoglobulin-containing suppressor of T-cell activation (VISTA) at acidic pH and their use in cancer treatment. In some embodiments, the antibodies bind specifically to human VISTA at acidic pH, but do not significantly bind to human VISTA at neutral or physiological pH.

Antibodies binding to VISTA at acidic pH

Provided herein are antibodies, or antigen binding portions thereof, that bind to T-cell immunoglobulin and mucin-domain containing-3 (TIM3) protein. Also provided are uses of these antibodies, or antigen binding portions thereof, in therapeutic applications, such as treatment of cancer. Further provided are cells that produce the antibodies, or antigen binding portions thereof, polynucleotides encoding the heavy and/or light chain regions of the antibodies, or antigen binding portions thereof, and vectors comprising the polynucleotides encoding the heavy and/or light chain regions of the antibodies, or antigen binding portions thereof.

Growing community of inventors

San Mateo, CA, United States of America

Andy X Deng