Seahorse Bioscience

Flir Systems Boston, Inc.

Thermogenic Imaging, Inc.

Seahorse Biosciences

Agilent Technologies, Inc.

Andy C Neilson

Jay S Teich

Michael R Sweeney

Geoff Uhl

Stephen C Young

Jim Orrell

James D Orrell, Iii

John M Hopkins

Michael W Oster

Paul McGarr

Suzanne Armitstead

Yevgeniy Margolin

Stephen G Young

Marc Samson

Marc Sampson

Devices and methods that measure one or more properties of a living cell culture that is contained in liquid media within a vessel, and typically analyzes plural cell cultures contained in plural vessels such as the wells of a multiwell microplate substantially in parallel. The devices incorporate a sensor that remains in equilibrium with, e.g., remains submerged within, the liquid cell media during the performance of a measurement and during addition of one or more cell affecting fluids such as solutions of potential drug compounds.

Cell analysis apparatus and method

An apparatus including a plurality of wells for conducting analysis of three-dimensional cell samples (e.g., tissue samples) and methods for experimenting with a three-dimensional sample. A removable insert for use with the apparatus enables plunger-driven perfusion of the three-dimensional sample.

Apparatus and methods for three-dimensional tissue measurements based on controlled media flow

A method of analyzing cells disposed in media within a vessel includes the steps of providing a vessel having an original volume of media about the cells, reducing the original volume of media about at least a portion of the cells to define a reduced volume of media, and analyzing a constituent related to the cells within the reduced volume of media. An apparatus for analyzing cells includes a stage adapted to receive a vessel holding cells and a volume of media, a plunger adapted to receive a barrier to create a reduced volume of media within the vessel including at least a portion of the cells, the barrier adapted for insertion into the vessel by relative movement of the stage and the plunger, and a sensor in sensing communication with the reduced volume of media, wherein the sensor is configured to analyze a constituent disposed within the reduced volume.

Method and device for measuring multiple physiological properties of cells

The accuracy and/or precision of measurements of extracellular acidification rate or COevolution in cell culture medium may be improved by using materials with low COpermeability for medium-containing vessels.

Method and device for measuring extracellular acidification and oxygen consumption rate with higher precision

Apparatus and methods for performing calorimetry. The apparatus include optical devices for detecting thermal processes and multiwell sample plates for supporting samples for use with such optical devices. The methods include measurement strategies and data processing techniques for reducing noise in measurements of thermal processes. The apparatus and methods may be particularly suitable for extracting thermal data from small differential measurements made using an infrared camera and for monitoring chemical and physiological processes.

Apparatus and methods for infrared calorimetric measurements

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Groton, MA, United States of America

Andy C Neilson