Hoffmann-La Roche Inc.

F. Hoffmann-La Roche Ag

Andrés Miguel Olivares Morales

Luca Claudio Gobbi

Bjoern Bartels

Giuseppe Cecere

Valerie Runtz-Schmitt

Maria-Clemencia Hernandez

Angélique Patiny-Adam

Guido Galley

Roland Humm

Andreas Koblet

Christian Schnider

The invention provides novel heterocyclic compounds having the general formula (I), and pharmaceutically acceptable salts thereof, wherein the variables are as described herein. Further provided are pharmaceutical compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds as medicaments, in particular methods of using the compounds for the treatment or prevention of acute neurological disorders, chronic neurological disorders and/or cognitive disorders.

Benzodiazepine derivatives as GABA A gamma 1 PAM

The invention provides novel heterocyclic compounds having the general formula (I) or (II), and pharmaceutically acceptable salts thereof, wherein the variables are as described herein. Further provided are pharmaceutical compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds as medicaments, in particular methods of using the compounds for the treatment or prevention of acute neurological disorders, chronic neurological disorders and/or cognitive disorders.

Benzodiazepine derivatives as GABA a GAMMA1 PAM

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Binningen, Switzerland

Andrés Miguel Olivares Morales