Matriq Ag

Corflow Therapeutics Ag

Epymetrics Ag

André Bernard

Klaus Dietrich

Mathias Mächler

Robert S Schwartz

Jon Helge Hoem

Peter Heeb

Dominik Obrist

Francesco Clavica

Sabrina Frey

Raphael Jäger

Cornelia Nef

Samuel Affolter

Vreni Lutz

Jan Grünenfelder

Oliver Bludau

Martin Gutsche

Emine Cagin Bertsch

Emine Cagin

Monika Baur

Systems, methods and apparatus are included that are configured to model microvascular obstruction (MVO) in patients. According to one aspect of the present disclosure, a multi-scale model is configured to mimic myocardial microcirculation of coronary vessels. The model includes collaterals configured to provide alternative pathways possibly bypassing the MVO, and configured to model coronary artery compliance for spatially resolved fluid transport through the coronary vessels. The model is configured to simulate the MVO by increasing flow resistance in at least one of the modelled coronary vessels, or by blocking the at least one of the modelled coronary vessels completely. The model is also configured to mimic behavior of fluid transport in the coronary vessels during diagnostics or treatment, to design and optimize therapy protocols for the MVO.

Microfluidic coronary circulatory model

A method for marking a workpiece () uses a device, wherein the workpiece () is formed at least partially in a thermal master or forming process, comprises a surface () directed towards the workpiece (), wherein a number of individually controllable heating elements () is distributed behind the surface () for a local heating of a workpiece surface portion. Each of the heating elements () comprises a solid material () having a surface structure and a heating structure (), wherein the surface () directed towards the workpiece () encompassing the surface structures () has a uniform smooth surface allowing to dark, burn or foam the surface () of the workpiece () through heat introduction.

Method and device for in situ marking a workpiece in a thermal forming process

A device for marking a work piece that is at least partially formed or reshaped through a thermal process is provided. The device includes a plurality of heating elements distributed laterally on a surface that is placed against the work piece and can be individually controlled for local heating of a work piece surface. Each of the heating elements includes a solid material with a surface structure and a heating structure. The surface structure includes at least one of a specifically or randomly varied topography. The surface structure can be at least partially heated through the heating structure.

Mold and device for marking work pieces

Growing community of inventors

St. Gallen, Switzerland

André Bernard