Richter Gedeon Nyrt.

Linn High Therm Gmbh

Alfoldi Malomipari Rt.

András Vass

Horst Linn

József Dudás

László Borbély

Ferenc Haász

Péter Jekkel

Ivánné Pallai

János Kovacs

István Edes

The invention relates to a process for the preparation of a phenolic hydroxy-substituted compound of the general formula (I) by desalkylation of an alkyl aryl ether of the general formula (II) by treatment with a thiourea/aluminum chloride reagent pair, in said general formulae Rstands for straight chain or branched Calkyl group; R, R, R, R, and Rhave the same or different meanings and stand for hydrogen or halogen atom, hydroxy, carboxy, nitro, oxo, Calkylcarbonyl, straight chain or branched alkyl or -alkoxy, or aryl group, or Rand Rtogether stand for a 5-7 membered ring or fused ring system; said 5-7 membered ring may be a partially saturated ring optionally substituted with an oxo group or can be an unsaturated ring; or said fused ring system may constitute with the first ring a steroid, preferably an estratriene derivative optionally substituted with an oxo or Calkylcarbonyloxy group in the 17 position. 

Process for the preparation of phenolic hydroxy-substituted compounds

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Veszprém, Hungary

András Vass