Adamed Sp. Z O.o.

Andrzej Wojciech Sawicki

Katarzyna Joanna Matusiewicz

Tomasz Stawinski

Zbigniew Majka

Katarzyna Ewa Rusin

Daniel Sulikowski

Krzysztof Kurowski

Piotr Kowalczyk

Dominik Daniel Kludkiewicz

Andrzej Trzepalka

Malgorzata Adamkiewicz

The invention relates to new compounds, being 3-phenylpropionic acid derivatives of formula I wherein W represents COOH group or its bioisosters, or &#x2014;COO&#x2014;C-C-alkyl group; Y represents NH, N&#x2014;C-C-alkyl, O, or S; Z represents NH, N&#x2014;C-C-alkyl, N-aryl, N-heteroaryl, S, or O; X represents O, S, NH, N&#x2014;C-C-alkyl, N-aryl, NSO&#x2014;C-C-alkyl, N&#x2014;SO-aryl, or N&#x2014;SO-heteroaryl; R, to Reach independently represent hydrogen atom or a substituent defined in the description; A is as defined in the description; n represents an integer from 0 to 4, inclusive; and pharmaceutically acceptable salts thereof. The compounds are the ligands of PPAR-gamma receptor and are useful as medicaments. 

3-phenylpropionic acid derivatives

The invention relates to new compounds, being 3-phenylpropionic acid derivatives of formula I wherein W represents COOH group or its bioisosters, or &#x2014;COO&#x2014;C-C-alkyl group; Y represents NH, N&#x2014;C-C-alkyl, O, or S; Z represents NH, N&#x2014;C-C-alkyl, N-aryl, N-heteroaryl, S, or O; X represents O, S, NH, N&#x2014;C-C-alkyl, N-aryl, NSO&#x2014;C-C-alkyl, N&#x2014;SO-aryl, or N&#x2014;SO-heteroaryl; Rto Reach independently represent hydrogen atom or a substituent defined in the description; A is as defined in the description; n represents an integer from 0 to 4, inclusive; and pharmaceutically acceptable salts thereof. The compounds are the ligands of PPAR-gamma receptor and are useful as medicaments 

The invention relates to new compounds, 3-phenylpropionic acid derivatives of formula (I) wherein W represents COOH group or its bioisosters, or &#x2014;COO&#x2014;C&#x2013;C-alkyl group; Y represents NH, N&#x2014;C&#x2013;C-alkyl, O, or S; X represents O, S, NH, N&#x2014;C&#x2013;C-alkyl, N-aryl, NSO&#x2014;C&#x2013;C-alkyl, N&#x2014;SO-aryl, or N&#x2014;SO-heteroaryl; Rto Reach independently represents hydrogen atom or a substituent defined in the description; A is as defined in the description; n represents an integer from 0 to 4, inclusive; and pharmaceutically acceptable salts thereof. The compounds are the ligands of PPAR-gamma receptor and are useful as medicaments 

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Jozefow, Poland

Andrzej Wojciech Sawicki