Thomas Jefferson University

Andrzej Steplewski

Andrzej Fertala

A chimeric, humanized or single-chain antibody contains a light chain variable region containing the complementarity determining regions of SEQ ID NO: 1, SEQ ID NO:2 and SEQ ID NO:3, and a heavy chain variable region containing the complementarity determining regionsSEQ ID NO:4,SEQ ID NO:5 and SEQ ID NO:6. The antibody or antibody fragment thereof is capable of binding the C-terminal telopeptide of the &#x3b1;2(I) chain of human collagen I, and is useful in the treatment of diseases or disorders associated with excessive collagen fibril.

Engineered antibody for inhibition of fibrosis

A chimeric, humanized or single-chain antibody contains a light chain variable region containing the complementarity determining regions of SEQ ID NO: 1, SEQ ID NO:2 and SEQ ID NO:3, and a heavy chain variable region containing the complementarity determining regions SEQ ID NO:5 and SEQ ID NO:6. The antibody or antibody fragment thereof is capable of binding the C-terminal telopeptide of the &#x3b1;2(I) chain of human collagen I, and is useful in the treatment of diseases or disorders associated with excessive collagen fibril.

A chimeric, humanized or single-chain antibody contains a light chain variable region containing the complementarity determining regions of SEQ ID NO:1, SEQ ID NO:2 and SEQ ID NO:3, and a heavy chain variable region containing the complementarity determining regions SEQ ID NO:5 and SEQ ID NO:6. The antibody or antibody fragment thereof is capable of binding the C-terminal telopeptide of the &#x3b1;2(I) chain of human collagen I, and is useful in the treatment of diseases or disorders associated with excessive collagen fibril.

A chimeric, humanized or single-chain antibody contains a light chain variable region containing the complementarity determining regions of SEQ ID NO: 1, SEQ ID NO:2 and SEQ ID NO:3, and a heavy chain variable region containing the complementarity determining regions SEQ ID NO:4, SEQ ID NO:5 and SEQ ID NO:6. The antibody or antibody fragment thereof is capable of binding the C-terminal telopeptide of the &#x3b1;2(I) chain of human collagen I, and is useful in the treatment of diseases or disorders associated with excessive collagen fibril.

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Phoenixville, PA, United States of America

Andrzej Steplewski