The State University of New York

Andriy Tsupryk

Vera Gorfinkel

Boris Gorbovitski

Dmytro Gudkov

Georgiy Gudkov

Ivan Tovkach

Dmitriy Gavrilov

Michael Gorbovitski

A fiberized single photon sensitive spectrometer based on a 32-channel PMT sensor is highly sensitive with broad detection dynamic range. The spectrometer enables accurate and high speed detection, identification and analysis of biological samples labeled with multiple fluorescent markers, such as compositions of multi-color fluorescence signals or radiation emitted by multiple fluorescence dyes. A fiberized optical input of the spectrometer allows an easy and efficient coupling to any measurement system based on fiber collection of the analyzed fluorescence. The spectrometer provides highly accurate DNA sequencing. A 32 channel PMT single photon detector has a detection dynamic range of more than 20 bits and has a frame rate of about 3300 frames per second. The dynamic range of the detector's pixels reaches 10photocounts per second.

Single photon spectrometer

The invention relates to devices that contain linear channels having optically transparent substances for focusing light. In some embodiments, the invention relates to improved nucleic acid sequencing methods using devices disclosed herein. In other embodiments, the invention relates to the arrangement of materials in and around capillary tubes with refractive indexes that maximize the number of channels useful for fluorescent detection of compositions after capillary electrophoresis.

Light focusing in linear channel arrays

Growing community of inventors

Coram, NY, United States of America

Andriy Tsupryk