Cayman Chemical Company Incorporated

Andriy Komilov

Stephen Douglas Barrett

James Bernard Kramer

Gregory William Endres

Kirk M Maxey

Adam Uzieblo

Fred Lawrence Ciske

Bradlee David Germain

Joseph Michael Colombo

Thomas Allen Owen

James Paul O'Malley

Disclosed herein are compounds of formula (I) and therapeutic methods of treatment with compounds of formula (I), wherein L, L, L, R, R, R, R, and s are as defined in the specification. Compounds of formula (I) are EP4 agonists useful in the treatment of glaucoma, neuropathic pain, and related disorders.

Difluorolactam compounds as EPreceptor-selective agonists for use in the treatment of EP-mediated diseases and conditions

Disclosed herein are compounds of formula (I) wherein L, L, L, L, R, R, R, R, and s are as defined in the specification. Compounds of formula (I) are EPagonists useful in the treatment of glaucoma, osteoporosis, bone fracture, periodontal bone loss, orthopedic implant, alopecia, neuropathic pain, and related disorders. Pharmaceutical compositions and methods of treating conditions or disorders are also described.

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Ypsilanti, MI, United States of America

Andriy Komilov