Celgene Corporation

Signal Pharmaceuticals, Inc.

Andrew Wurmser

Jeonghoon Sun

Shuichan Xu

Jennifer Riggs

John Frederick Boylan

Kandasamy Hariharan

Henry Chan

Dan Zhu

David Mikolon

Mahan Abbasian

Tao Shi

Gordafaried Deyanat-Yazdi

Antibody species that bind B-Cell Maturation Antigen (BCMA) are provided as well as methods of depleting BCMA-expressing cells in a patient in need thereof, comprising administering a therapeutically effective amount of the antibody species or an entity comprising a BCMA binding fragment thereof. Methods of treating B cell-related disorders associated with BCMA expression in a patient in need thereof are provided, comprising administering to the patient a therapeutically effective amount of the antibody species or an entity comprising a BCMA binding fragment thereof.

BCMA-binding antibodies and uses thereof

Provided herein are methods for treating or preventing a cancer, in particular solid tumors and hematological cancers, comprising administering to a subject in need thereof an effective amount of a compound of formula (I): 

Methods of treating a cancer using substituted pyrrolopyrimidine compounds, compositions thereof

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San Diego, CA, United States of America

Andrew Wurmser