Raindance Technologies, Inc.

Bio-rad Laboratories, Inc.

Gen9, Inc.

Visen Medical, Inc.

Andrew Wilson

Darren Roy Link

Jonathan William Larson

Qun Zhong

Mark Weary

Benjamin J Miller

Yevgeny Yurkovetsky

Brian Hutchison

Joseph M Jacobson

Daniel Schindler

Li-yun A Kung

Senthil Ramu

Michael E Hudson

Wael I Yared

Mike Hudson

The invention provides methods for assessing one or more predetermined characteristics or properties of a microfluidic droplet within a microfluidic channel, and regulating one or more fluid flow rates within that channel to selectively alter the predetermined microdroplet characteristic or property using a feedback control.

Manipulation of microfluidic droplets

Methods and apparatus relate to the synthesis of polynucleotides having a predefined sequence on a support. Assembly methods include primer extension to generate overlapping construction oligonucleotides and assembly of the polynucleotides of interest onto an anchor support-bound oligonucleotides. Methods and apparatus for selection of polynucleotides having the predefined sequence and/or length are disclosed.

Methods and devices for nucleic acids synthesis

Methods and devices for nucleic acid synthesis

The invention facilitates transport of an immobilized, anesthetized small animal across multiple single-modality or multiple-modality imaging workstations at the same or different physical locations without loss of subject positional information. The animal holder is compatible with preclinical animal imaging stations such as micro-CT, micro-MR, micro-PET, micro-SPECT, and FMT. The animal holder is configured to be accommodated by (for example, fit within) individual imaging chambers of such instruments and is fabricated from materials that are compliant with all of the imaging modalities used. In certain embodiments, an integrated set of fiducial marker wells accommodates the dispensing of markers that are picked up by several modalities simultaneously in multiple planes. The fiducial markers then are aligned in standard image processing or image analysis software with simple image translation and rotation operations, without the need for more advanced scaling, distortion or other operations.

Animal holder for in vivo tomographic imaging with multiple modalities

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Arlington, MA, United States of America

Andrew Wilson