Saudi Arabian Oil Company

Durham University

M-i Drilling Fluids UK Limited

University of Durham

Durahm University

High Force Research Limited

Reinnervate Limited

Andrew Whiting

Gasan Selman Alabedi

Hugh Christopher Greenwell

John Adrian Hall

Manohara Gudiyor Veerabhadrappa

Michael Hayward Hodder

Musarrat Halima Mohammed

Mona Al Batal

David Chisholm

Abdullah Ayedh Al-Shahrani

Mark Coles

Todd Marder

Carrie Ambler

Iain Robert Greig

Stefan Przyborski

Peter McCaffery

Thabat Khatib

Peter Mccaffery

The present invention relates to compounds of formula I: in which A-Aand Rto Rare defined herein, for use in the treatment of a condition or disease which is alleviated by the activation of retinoic acid receptors (RAR). The invention also relates to pharmaceutical compounds comprising such compounds, and related methods of treatment. In an aspect, the invention relates to a method of screening compounds for therapeutic potential in the treatment of a condition or disease which is alleviated by the activation of retinoic acid receptors (RAR). Aspects of the invention relate to novel compounds of formula I in which at least one of Ato Ais N or at least one of Ais CRor Ais CRin which R/Ris halogen.

Synthetic retinoids for use in RAR activation

There are described novel compounds of formula I: (I) in which, in which A, A, A, A, Rand Rare each as herein defined, for use in the treatment or alleviation of an RAR mediated condition; and methods related thereto.

Synthetic retinoids (in cell modulation)

Methods for preparing a layered metal nanocomposite and a layered metal nanocomposite. The method includes mixing a magnesium salt and an aluminum salt to form a Mg/Alsolution. The Mg/Al has a molar ratio of between 0.5:1 to 6:1. Then a diamondoid compound is added to the Mg/Alsolution to form a reactant mixture. The diamondoid compound has at least one carboxylic acid moiety. The reactant mixture is heated at a reaction temperature for a reaction time to form a Mg/Al-diamondoid intercalated layered double hydroxide. The Mg/Al-diamondoid intercalated layered double hydroxide is thermally decomposed under a reducing atmosphere for a decomposition time at a decomposition temperature to form the layered metal nanocomposite.

Methods for preparing mixed-metal oxide diamondoid nanocomposites and catalytic systems including the nanocomposites

Oil-based drilling fluid compositions comprising an oil phase comprising a base oil, an aqueous phase comprising water, at least one emulsifier, and one or more additives. The at least one emulsifier comprises an amino amide comprising the formula R&#x2014;CO&#x2014;NH&#x2014;R'&#x2014;NH&#x2014;R&#x2033;&#x2014;NH, where R is a fatty acid alkyl and R&#x2032; and R&#x2033; are alkyl groups. The one or more additives are chosen from a wetting agent, a rheology modifier, a fluid-loss control additive, and a weighting additive. Methods of making the oil-based drilling fluid compositions and methods of drilling a subterranean well utilizing the oil-based drilling fluid compositions are also provided.

Oil-based drilling fluids for high pressure and high temperature drilling operations

A method of preparing and a composition of an oil-based drilling fluid. An oil-based drilling fluid includes a base oil continuous phase, in which the base oil continuous phase includes a base oil, an aqueous dispersed phase, and at least one rheology modifier comprising a modified magnesium/aluminum carbonate layered-double hydroxide (Mg/Al&#x2014;COLDH) compound.

Layered double hydroxides for oil-based drilling fluids

Oil-based drilling fluid compositions comprising an oil phase comprising a base oil, an aqueous phase comprising water, at least one emulsifier, and one or more additives. The at least one emulsifier comprises an amino amide comprising the formula R&#x2014;CO&#x2014;NH&#x2014;R'&#x2014;NH, where R is a fatty acid alkyl and R&#x2032; is an alkyl group. The one or more additives are chosen from a wetting agent, a rheology modifier, a fluid-loss control additive, and a weighting additive. Methods of making the oil-based drilling fluid compositions and methods of drilling a subterranean well utilizing the oil-based drilling fluid compositions are also provided.

Embodiments are directed to adamantane-intercalated layered double-hydroxide (LDH) particles and the methods of producing adamantane-intercalated LDH particles. The adamantane-intercalated LDH particles have a general formula defined by [MAl(OH)](A).mHO, where x is from 0.14 to 0.33, m is from 0.33 to 0.50, M is chosen from Mg, Ca, Co, Ni, Cu, or Zn, and A is adamantane carboxylate. The adamantane-intercalated LDH particles further have an aspect ratio greater than 100. The aspect ratio is defined by the width of an adamantane-intercalated LDH particle divided by the thickness of the adamantane-intercalated LDH particle.

Adamantane-intercalated layered double hydroxide

A method for preparing a transition-metal adamantane carboxylate salt is presented. The method includes mixing a transition-metal hydroxide and a diamondoid compound having at least one carboxylic acid moiety to form a reactant mixture, where M is a transition metal. Further, the method includes hydrothermally treating the reactant mixture at a reaction temperature for a reaction time to form the transition-metal adamantane carboxylate salt.

Synthesis of transition-metal adamantane salts and oxide nanocomposites, and systems and methods including the salts or the nanocomposites

Methods for preparing a layered metal nanocomposite and a layered metal nanocomposite. The method includes mixing a magnesium salt and a aluminum salt to form a Mg/Alsolution. The Mg/Al has a molar ratio of between 0.5:1 to 6:1. Then a diamondoid compound is added to the Mg/Alsolution to form a reactant mixture. The diamondoid compound has at least one carboxylic acid moiety. The reactant mixture is heated at a reaction temperature for a reaction time to form a Mg/Al-diamondoid intercalated layered double hydroxide. The Mg/Al-diamondoid intercalated layered double hydroxide is thermally decomposed under a reducing atmosphere for a decomposition time at a decomposition temperature to form the layered metal nanocomposite.

Embodiments for an oil-based drilling fluid and methods of making the oil-based drilling fluid are provided, in which the oil-based drilling fluid comprising: an oil phase; an aqueous phase; at least one surfactant, in which at least one surfactant comprises a carboxylic acid having 10 or more glycol repeating units; and optionally, at least one emulsifying agent.

Thermally stable surfactants for oil based drilling fluids

Embodiments are directed to a surfactant of formula (I) and incorporation of one or more surfactants into drilling fluids. The surfactant having the following structure: 

A drilling fluid and a method of preparing the drilling fluid. The oil-based drilling fluid includes a base oil continuous phase comprising a base oil, an aqueous dispersed phase and at least one rheology modifier. The at least one rheology modifier includes a magnesium/aluminum (Mg/Al) layered-double hydroxide (LDH) diamondoid compound.

There are described novel compounds of formula I: which R, R, R, R, R, R, R, R, Rand Rare each as herein defined. 

Fluorescent synthetic retinoids

The present application discloses drilling fluid compositions, methods for making drilling fluids, and methods for drilling subterranean wells utilizing the drilling fluids. According to one embodiment, a drilling fluid composition may include an oil phase, an aqueous phase, and a rheology modifier. The rheology modifier may include a layered double hydroxide, such as Mg/Al-Myristate layered double hydroxide.

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Durham, United Kingdom

Andrew Whiting