Children's Medical Center Corporation

Harvard College

Vital Biosciences, Inc.

Andrew Ward

Wesley Philip Wong

Darren Yang

Lisa Caldwell

Joshua John Forman

Mounir A Koussa

Ronald L Green

Kenneth Anders Halvorsen

Calvin Domenico

Clinton H Hansen

Mounir Ahmad Koussa

ArunRichard Chandrasekaran

Hongyu Zhao

Anthony Pulido

Eric M Mulhall

Padric Garden

Bradley Demarco

Christopher Blanchard

This disclosure provides methods for generating functionalized nanoswitches, as well as the functionalized nanoswitches themselves, and methods of use thereof.

Nucleic acid nanoswitch construction methods

An electrophoretic device for detecting biomarkers in collected bodily fluid and methods of using the same.

Gel electrophoresis diagnostic kit and methods of using the same

Provided herein, inter alia, are improved methods for detecting analytes, including proteins and nucleic acids. In some instances, the analytes are detected in complex matrices such as serum.

Rapid and sensitive detection and quantification of analytes in complex samples using polymer-based methods

An apparatus for measuring a characteristic of a sample using a centrifuge and optical components is disclosed. The centrifuge may be a standard benchtop centrifuge. The optical components may be sized and dimensioned to fit, along with the sample, inside the centrifuge.

Spinning apparatus for measurement of characteristics relating to molecules

The invention described herein provides, in part, improved methods, compositions, and kits for detecting analytes in biological samples.

Electrophoresis diagnostic methods and kits

The invention provides compositions comprising nucleic acid complexes for use in monitoring binding interactions and in measuring association and/or dissociation kinetics, detecting analytes including low concentration analytes, and screening library members. In some instances, the nucleic acid complexes are double-stranded nicked nucleic acids comprising a scaffold nucleic acid hybridized to one or more oligonucleotides. In some instances, a first, a second, a third, and optionally a fourth oligonucleotide are linked to moieties that are known to interact with each other or which are suspected of interacting with each other or of interacting with a common moiety such as an analyte. Changes in topology of the complex are used to determine the binding interactions of the various binding partners.

Nucleic acid-based linkers for detecting and measuring interactions

Growing community of inventors

Everett, MA, United States of America

Andrew Ward