Gilead Sciences, Inc.

Gilead Pharmasset LLC

Andrew W Waltman

Dustin S Siegel

Bruce Ross

Katie Ann Keaton

James G Taylor

Choung U Kim

Aesop Cho

Darryl Kato

Oliver L Saunders

Samuel E Metobo

Adam James Schrier

Thomas Butler

Michael Sangi

Lijun Zhang

Jie Xu

Ruben Martinez

Nathan D Shapiro

Kapil Kumar Karki

Jonathan Clive Tripp

Benjamin R Graetz

Norihiro Ikemoto

Troy Evan Reynolds

Denise A Colby

Nolan Griggs

Johann Chan

Dominika Pcion

Lina Chan

John Enquist, Jr

Donald Tang

Christopher Hale

Amy Cagulada

Chris Levins

Adam Littke

Pamela Seng

Lawrence Yu

Scott E Lazerwith

Xianghong Wang

Edward Doerffler

Robert William Scott

Willard Lew

Lars V Heumann

Katrien Brak

Silvio A Campagna

Anna Chiu

Andrew C Stevens

Tiago Vieira

Robert Ronald Milburn

Sean Timothy Neville

Pavel Robertovich Badalov

Andrei Chtchemelinine

Morin Mae Frick

Detian Gao

Mark Charles Whitcomb

Silvio Campagna

Erik Rueden

Matt Kraft

Michel Leeman

Zhihui Peng

Kate Schrier

Clarissa Tadeus

Jonathan Trinidad

Jochem Van Herpt

Steven Donald Axt

Lydia Wolfe

Chia-Yun Yu

Brittanie Hoang

Sudha Kondappally

Sudha Kondapally

John Enquist

Troy Reynolds

Jonathan Tripp

Dustin Siegel

Provided are methods of preparing compounds and pharmaceutical compositions comprising a compound Formula VIII for treating Filoviridae virus infections. In one aspect, the compound of Formula VIII is formed from a reaction mixture comprising the compound of Formula IX, the compound of Formula X, a coupling agent such as magnesium chloride and a non-nucleophilic base such as diisopropylethylamine. The compound of Formula IX can be formed from a compound of Formula V and a cyanating agent. The compound of Formula V can be synthesized from a reaction mixture comprising a deprotonating agent such as phenylmagnesium chloride; a silylating agent such as chlorotrimethylsilane; a coupling agent such as isopropylmagnesium chloride, an additive such as LaCl-2LiCl, LaCl, CeCl, NdCl, or YCl; a compound of Formula VI; and 7-iodopyrrolo[2,1-f][1,2,4]triazin-4-amine. The compounds, compositions, and methods provided are particularly useful for the treatment of Marburg virus, Ebola virus and Cueva virus infections.

Methods for the preparation of ribosides

Provided are processes and intermediates for the syntheses of nucleosides of pyrrolo[1,2-f][1,2,4]triazinyl and imidazo[1,2-f][1,2,4]triazinyl heterocycles of Formula I. 

Processes and intermediates for the preparation of 1'-substituted carba-nucleoside analogs

Methods of making compounds of Formula I are disclosed: 

Synthesis of polycyclic-carbamoylpyridone compounds

The present disclosure provides processes for the preparation of a compound of formula I: which is useful as an antiviral agent. The disclosure also provides compounds and processes for the preparation of the compounds that are synthetic intermediates to the compound of formula I.

Synthesis of an antiviral compound

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San Francisco, CA, United States of America

Andrew W Waltman