3m Innovative Properties Company

Andrew W Rabins

Kannan Seshadri

Manjiri T Kshirsagar

Robert T Fitzsimons, Jr

Catherine A Bothof

Masayuki Nakamura

Larry J Carson

Kelly J Gibbens

Michael R Berrigan

Jon A Kirschhoffer

Clinton P Waller, Jr

Douglas Eugene Weiss

Wensheng Xia

Evan Koon Lun Yuuji Hajime

Jeffrey A Lucas

Jerald K Rasmussen

James I Hembre

Del R Lawson

Taib K Ansera

Stephen M Larsen

Clinton P Waller

A process for capturing or concentrating microorganisms for detection or assay comprises (a) providing a concentration device comprising a sintered porous polymer matrix comprising at least one concentration agent that comprises an amorphous metal silicate and that has a surface composition having a metal atom to silicon atom ratio of less than or equal to 0.5, as determined by X-ray photoelectron spectroscopy (XPS); (b) providing a sample comprising at least one microorganism strain; and (c) contacting the concentration device with the sample such that at least a portion of the at least one microorganism strain is bound to or captured by the concentration device.

Microorganism concentration process and device

A process for capturing or concentrating microorganisms for detection or assay comprises (a) providing a concentration device comprising a sintered porous polymer matrix comprising at least one concentration agent that comprises diatomaceous earth bearing, on at least a portion of its surface, a surface treatment comprising a surface modifier comprising ferric oxide, titanium dioxide, fine-nanoscale gold or platinum, or a combination thereof; (b) providing a sample comprising at least one microorganism strain; and (c) contacting the concentration device with the sample such that at least a portion of the at least one microorganism strain is bound to or captured by the concentration device.

A bismuth-containing concentration agent for microorganisms is provided. Additionally, articles that include the concentration agent and methods of concentrating a microorganism using the concentration agent are provided.

Bismuth-containing concentration agents for microorganisms

A first apparatus for processing a liquid sample is disclosed. The apparatus includes a sample-receiving, a filtrate-receiving component, and an analyte-capture element. The apparatus forms a liquid flow path through which the sample passes, thereby causing the analyte-capture element to capture an analyte, if present. A method is disclosed whereby a liquid sample is passed through the first apparatus and the analyte-capture element is easily separated from the apparatus for further processing and detection of the analyte. A structurally-related second apparatus for processing a plurality of liquid samples, and a corresponding method of use, also is disclosed.

Apparatus and method for processing a sample

A concentration agent for microorganisms is provided that contains both lanthanum and carbonate. Additionally, articles that include the concentration agent and methods of concentrating a microorganism using the concentration agent are provided.

Lanthanum-based concentration agents for microorganisms

A first apparatus () for processing a liquid sample is disclosed. The apparatus () includes a sample-receiving (), a filtrate-receiving component (), and an analyte-capture element (). The apparatus () forms a liquid flow path through which the sample passes, thereby causing the analyte-capture element () to capture an analyte, if present. A method is disclosed whereby a liquid sample is passed through the first () apparatus and the analyte-capture element () is easily separated from the apparatus for further processing and detection of the analyte. A structurally-related second apparatus () for processing a plurality of liquid samples, and a corresponding method of use, also is disclosed.

Semi-interpenetrating polymeric networks are described. More specifically, the semi-interpenetrating polymeric networks include at least two polymers that are closely associated. The first polymer is an ionic polymer that is not crosslinked. The second polymer is a cross-linked polymer that can be either another ionic polymer or a non-ionic polymer. Methods of making the semi-interpenetrating polymeric networks, articles containing the semi-interpenetrating polymeric networks, and methods of using the semi-interpenetrating polymeric networks are also described. The semi-interpenetrating polymeric networks can function as ion exchange resins.

Semi-interpenetrating polymer network

A single pass simulated moving bed apparatus and methods are described for continuously separating a target molecule from a liquid mixture, using a simulated moving bed system. The simulated moving bed system includes a plurality of filter cartridge modules in serial fluid communication. Each filter cartridge module includes a volume of stationary phase particulates adjacent a porous substrate layer. The volume of stationary phase particulates has a bed height of less than 1 centimeter.

Single pass method and apparatus for separating a target molecule from a liquid mixture

A grafted nonwoven substrate is disclosed having average fiber sizes of 0.7 to 15 microns, and a void volume of 50 to 95%, and a polymer comprising cationic aminoalkyl(meth)acryloyl monomer units grafted to the surface of the nonwoven substrate. The article may be used as a filter element to purify or separate target materials, such as oligonucleotides or monoclonal antibodies (MAb), from a fluid mixture.

Functionalized nonwoven article

A simulated moving bed apparatus and methods are described for continuously separating a target molecule from a liquid mixture, using a simulated moving bed system. The simulated moving bed system includes a plurality of filter cartridge modules in serial fluid communication. Each filter cartridge module includes a volume of stationary phase particulates adjacent a porous substrate layer. Each filter cartridge module also includes recirculation piping in fluid connection with a filter cartridge outlet and a filter cartridge inlet.

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Saint Paul, MN, United States of America

Andrew W Rabins