Ichor Medical Systems, Inc.

Janssen Sciences Ireland Unlimited Company

Ichor Medical Systmes, Inc.

Papivax Biotech Inc.

Andrew W Hannaman

Robert M Bernard

Brady M Bernard

Steven Masterson

Stephen A Morse

Adam Hartman

Oliver Ruck

Thomas David Cox

Soumitra Roy

Jean-Marc Edmond Fernand Marie Neefs

Daniel Boden

Helen Horton

Dorien De Pooter

Silvia Sfiligoi

Steven P Masterson

Methods and apparatus for the reproducible, consistent and efficacious delivery of an HBV vaccine to a subject. The disclosure comprises apparatus for the controlled administration of the HBV vaccine through an orifice to the subject, a plurality of penetrating electrodes arranged with a predetermined spatial relationship relative to the orifice, and an electrical signal generator operatively connected to the electrodes.

Methods and apparatus for the delivery of hepatitis B virus (HBV) vaccines

Methods and apparatus for the reproducible, consistent and efficacious delivery of a therapeutic agent to a subject. The present disclosure comprises apparatus for the controlled administration of the therapeutic agent through an orifice to the subject, a plurality of penetrating electrodes arranged with a predetermined spatial relationship relative to the orifice, and an electrical signal generator operatively connected to the electrodes.

Method and apparatus for delivery of therapeutic agents

Apparatus for the delivery of an electrical field which facilitates the intracellular delivery of a therapeutic agent to a predetermined site within the tissue of a patient. The apparatus will comprise a plurality of penetrating electrodes arranged in a predetermined spatial relationship, each electrode with a cross sectional area contributing to the total cross sectional area of all electrodes, and structural means incorporating an inanimate source of energy operatively connected to the plurality of electrodes for deploying the electrodes, wherein the source of energy is sufficient to impart a force of at least 1000 pounds per square inch (0.7 kilogram per square millimeter) of total cross sectional area of all electrodes at the initiation of the deployment of the electrodes. The apparatus will also comprise means for generating an electrical field which facilitates the intracellular delivery of a therapeutic agent, which means is operatively connected to said electrodes at least in their deployed state.

Apparatus for electrically mediated delivery of therapeutic agents

Methods and apparatus for the reproducible, consistent and efficacious delivery of a therapeutic agent to a patient. The invention comprises means for the controlled administration of the therapeutic agent through an orifice to the patient, a plurality of penetrating electrodes arranged with a predetermined spatial relationship relative to the orifice, and means for generating an electrical signal operatively connected to the electrodes.

Method and apparatus for the reproducible, consistent and efficacious delivery of a therapeutic agent to a patient. The invention comprises means for the controlled administration of the therapeutic agent () through an orifice to the patient, a plurality of penetrating electrodes () arranged with a predetermined spatial relationship relative to the orifice (), and means for generating an electrical signal operatively connected to the electrodes.

Methods for improving the efficiency of electroporation protocols as well as methods to enhance the permeabilized state, in order to improve the intracellular delivery of therapeutic substances, involve the use of at least one agent which is capable of prolonging the permeability of the cell membranes in the tissue exposed to an electroporation-inducing electrical field.

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San Diego, CA, United States of America

Andrew W Hannaman