Retrophin, Inc.

Sgx Pharmaceuticals, Inc.

Celmed Oncology (usa), Inc.

Biestek, Marek

Shkreli, Martin

Vaino, Andrew

Andrew Vaino

Marek Biestek

Martin Shkreli

H Michael Shepard

Pierre-Yves Bounaud

Danielle M Lehsten

Compounds having the following formula (E): or a pharmaceutically acceptable salt thereof, wherein R, R', R&#x2033;, X and n are as defined herein are provided. Methods comprising use of such compounds for the treatment of neurologic disorders, such as pantothenate kinase-associated neurodegeneration, and pharmaceutical compositions containing such compounds, and their use in treatment of neurologic disorders are also provided.

Pantothenate derivatives for the treatment of neurological disorders

Compounds having the following formula (E): Formula E or a pharmaceutically acceptable salt thereof, wherein R, R', R&#x2033;, X and n are as defined herein are provided. Methods comprising use of such compounds for the treatment of neurologic disorders, such as pantothenate kinase-associated neurodegeneration, and pharmaceutical compositions containing such compounds, and their use in treatment of neurologic disorders are also provided. 

The present disclosure relates to pantothenate derivatives for the treatment of neurologic disorders (such as pantothenate kinase-associated neurodegeneration), pharmaceutical compositions containing such compounds, and their use in treatment of neurologic disorders.

Pantothenate derivatives for the treatment of neurologic disorders

The present invention provides novel bicyclic pyrazolo kinase modulators and methods of using the novel bicyclic pyrazolo kinase modulators to treat diseases mediated by kinase activity.

Bicyclic pyrazolo protein kinase modulators

This invention provides compounds, compositions and methods for treating cancer, infectious disease, an autoimmune disorder or an inflammatory condition. Therapeutic compounds useful in the methods of this invention are 5'-phosphoramidatyl, 1,5-substituted pyrimidine compounds, derivatives, analogs and pharmaceutically acceptable salts thereof.

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San Diego, CA, United States of America

Andrew Vaino