Gen9, Inc.

Seattle Biomedical Research Institute

Combimatrix Corporation

US Government As Represented by the Secretary of the Army

The United States of America As Represented by the Army

Andrew V Oleinikov

Patrick Emmet Duffy

Michal Fried

Jason P Wendler

Susan Francis

Theonest K Mutabingwa

There is disclosed a process for in vitro synthesis and assembly of long, gene-length polynucleotides based upon assembly of multiple shorter oligonucleotides synthesized in situ on a microarray platform. Specifically, there is disclosed a process for in situ synthesis of oligonucleotide fragments on a solid phase microarray platform and subsequent, 'on device' assembly of larger polynucleotides composed of a plurality of shorter oligonucleotide fragments.

Microarray synthesis and assembly of gene-length polynucleotides

The invention provides isolated placentalpolypeptides comprising an amino acid sequence selected from the group consisting of SEQ ID NOs:1-4 and 6-24, and immunogenic derivatives thereof. The invention also provides isolated nucleic acid molecules encoding the placentalpolypeptides of the invention, compositions comprising one or more placentalpolypeptides of the invention, methods for inducing an immune response against the placentalpolypeptides, and methods for treating and diagnosing placental malaria.

Malaria vaccines

Growing community of inventors

Mill Creek, WA, United States of America

Andrew V Oleinikov