University of Pennsylvania

The Penn State Research Foundation

Andrew Tsourkas

James Z Hui

Burcin Altun

David Cormode

Feifan Yu

Hejia Henry Wang

Jayesh P Thawani

Harry R Allcock

Daniel J Powell

Anatoliy V Popov

Andrew D A Maidment

E James Delikatny

Jared M Pisapia

Hongjie Zhu

Roshan Karunamuni

M Sean Grady

Ahmad Amirshaghaghi

Ajlan Al Zaki

Lesan Yan

Zhiliang Cheng

Peter Chhour

Fabiana Zappala

Antony Kuang-Shih Chen

Sara Gavenonis

Rabe'e Cheheltani

Robert Warden-Rothman

The invention provides novel compositions and methods for the detection of a target molecule. Specifically, the invention provides a bimolecular beacon composition comprising two nucleic acid molecules, and methods thereof. One of the nucleic acid molecule is operably linked to a reporter detectable label and the other nucleic acid molecule is operably linked to a reference detectable label and a quencher. In some embodiments, at least one of the nucleic acid molecules comprises a single stranded overhang.

Molecular beacons

The invention relates to antibody conjugates (e.g., a bispecific antibody), drug and nanoparticle compositions and methods and compositions for generating them. This invention further relates to methods of using these compositions for imaging, diagnosing or treating a disease.

Compositions and methods for making antibody conjugates

This invention relates to conjugate antibody, drug and nanoparticle compositions and methods of generating the same. This invention further relates to methods of using same for imaging, diagnosing or treating a disease.

Method for the site-specific covalent cross-linking of antibodies to surfaces

The invention relates to proximity-based sortase-mediated protein purification and ligation. Specifically, the invention relates to techniques that links protein expression/purification with conjugation to therapeutic agents, imaging agents, or linkers.

Proximity-based sortase-mediated protein purification and ligation

A bispecific cytotoxic lymphocyte or macrophage-redirecting autoantibody comprising a cytotoxic lymphocyte or macrophage targeting domain and an autoantibody. Methods for producing bispecific cytotoxic lymphocyte or macrophage-redirecting autoantibody comprising a cytotoxic lymphocyte or macrophage targeting domain and an autoantibody. Methods for treating a subject in need thereof comprising administering to the subject an isolated bispecific cytotoxic lymphocyte or macrophage-redirecting autoantibody.

Bispecific cytotoxic lymphocyte or macrophage-redirecting autoantibodies, methods for production thereof and methods of treatment

The invention relates to amphiphilic dye-coated inorganic nanoparticle clusters and uses thereof. Specifically, the invention relates to cyanine and/or cyclic tetrapyrrole dye-coated metallic nanoparticle clusters for use in medical imaging and treatments.

Amphiphilic dye-coated inorganic nanoparticle clusters

An ultrasonication apparatus is provided for improving catheter function. The ultrasonication apparatus includes a transducer configured to produce ultrasonic waves for ultrasonication and a chamber for containing a fluid having a passage for receiving a catheter. The chamber is adapted to receive the ultrasonic waves from the transducer.

Apparatus and methods for improving catheter function

The invention provides compositions and methods for adoptive T cell therapy in treating a variety of disorders including cancer, infections, and autoimmune disorders. In one embodiment, the invention provides a universal immune receptor that comprises a protein or peptide tag, such as a SpyCatcher or a SpyTag moiety, bound to an extracellular hinge region, a transmembrane domain, and an intracellular domain for T cell activation.

SpyCatcher and SpyTag: universal immune receptors for T cells

Contrast agents for x-ray imaging including stabilized metal nanoparticles and encapsulated nanoparticles, as well as methods for imaging tissue with these agents, are disclosed. Also disclosed are methods of dual energy x-ray imaging using metal nanoparticle contrast agents or encapsulated metal nanoparticles.

Radiographic contrast agents for temporal subtraction and dual-energy x-ray imaging

Nanoclusters comprising inorganic nanocrystals and a biodegradable polymer are disclosed. The inorganic nanocrystals have a mean particle size of 1 to 500 nm. The inorganic nanocrystals are contained within a core of the nanoclusters, on the surface of the nanoclusters, contained within a core of the nanoclusters, dispersed throughout the nanoclusters, or a combination thereof. The biodegradable polymer allows the inorganic nanocrystals to be excreted renally over a period of time. The nanoclusters can be used for medical imaging or other biomedical applications.

Polyphosphazene delivery system for inorganic nanocrystals

The invention relates to a sortase-mediated protein purification and ligation. Specifically, the invention relates to a technique that links protein expression/purification with conjugation to therapeutic agents, imaging agents, or linkers.

Growing community of inventors

Bryn Mawr, PA, United States of America

Andrew Tsourkas