Kimberly-clark Worldwide, Inc.

Sorrento Therapeutics, Inc.

Avent, Inc.

Vivasor, Inc.

Andrew Thomas Baker

Russell Frederick Ross

Elizabeth Deibler Gadsby

Luke Hagan

Sridhar Ranganathan

Charles Wilson Colman

Stephen Avedis Baratian

Theresa Michelle McCoy

Shawn Jeffrey Sullivan

Pratap Ganapathy

Alyson Yamada

Aaron Peck

Ralph Solarski

Kenneth John Zwick

Kaiyuan Yang

Phillip A Schorr

Audra Stefanik Wright

Kok-Ming Tai

Linda Connor Sledge

Jin Seong Heo

Dave Allen Soerens

David William Koenig

Andrew Mark Long

Timothy James Blenke

Jeffrey Eldon Fish

Thomas Michael Ales

Fred R Radwanski

Donald Eugene Waldroup

Edward A Colombo

Joseph A Cesa

Brian Joseph Cuevas

Carl Gerard Rippl

Marvin E Swails

Darold Dean Tippey

Alison Salyer Bagwell

Michael Joseph Garvey

Davis Dang Hoang Nhan

Scott M Teixeira

Joseph R Feldkamp

WanDuk Lee

Adrienne A Hershey

Shawn Jeffery Sullivan

Joseph Earl Pierce

Jose Kollakompil Abraham

Jeffrey Robert Heller

Kathleen C Engelbrecht

Jeffrey Jennings Krueger

Francis P Abuto

Waihong Leong

Emily A Reichart

Divesh Bhatt

Jeanne Marie Gatto

Benone Tarcau

Jennifer S Stadelman

Mary F Mallory

James M Takeuchi

Dwayne J-k Jackson

Amy G Williams

Joel P Anderson

Jeff Heller

David P Pollock

Dwayne J-K Jackson

Russel E Ross

Russel F Ross

Iii Thomas Michael Ales

A one-ply absorbent article comprising a nonwoven first layer; a non-woven third layer; a nonwoven second layer between the first layer and the third layer; and wherein the one-ply absorbent article has a first absorbency measure at a first delamination state and a second absorbency measure at a second delamination state, wherein the first absorbency measure is less than the second absorbency measure and the first delamination state is less than the second delamination state.

Absorbent articles and methods for manufacturing same

A microneedle array assembly includes a microneedle array that has a plurality of microneedles. A distribution manifold includes a fluid supply channel that is coupled in flow communication to a plurality of resistance channels. Each of the resistance channels are coupled in flow communication to a respective one of the microneedles of the microneedle array. The resistance channels have a resistance value to a fluid flow through each resistance channel that is in the range between about 5 times greater to about 100 times greater than a resistance to the fluid flow through the supply channel.

Microneedle array assembly and fluid delivery apparatus having such an assembly

A fluid delivery apparatus includes a collet assembly having an upper and lower wall attached at a central portion of the collet. The central portion defines an inner step, and the lower wall includes circumferentially-spaced flexible tabs. The fluid delivery apparatus also includes a fluid distribution assembly coupled to the collet assembly. The fluid distribution assembly is positionable relative to the collet between a pre-use configuration and a pre-activated configuration. The fluid distribution assembly has a plenum that includes a sleeve component having an exterior ledge extending thereabout. A lower wall portion of the sleeve component includes protrusions corresponding to the flexible tabs of the collet. In the pre-use configuration the exterior ledge of the sleeve component is engaged with the inner step of the collet assembly, and each flexible tab engages a respective protrusion to provide a snap-fit between the fluid distribution assembly and the collet assembly.

Fluid delivery apparatus and method of assembly

A controller assembly of a fluid delivery apparatus includes a body component and a plunger component slidably coupled to the body component. The plunger is positionable between a first position in which the plunger is nearest to the body component, and a second position in which the plunger component is furthest from the body component. A bias assembly positioned between the body component and the plunger component applies a two stage force profile to the plunger component. The bias assembly includes a first and a second biasing member. In the first position, the first and second biasing members apply first and second forces profiles, respectively, to the plunger component. In the second position, the first biasing member is prevented from applying the first force profile to the plunger component, and the second biasing member applies the second force profile to the plunger component.

Fluid delivery apparatus having a controller assembly and method of use

A transdermal drug delivery apparatus includes a receptacle having a housing and a microneedle assembly mounted to the housing. The apparatus includes a reservoir for being mounted to the receptacle. The reservoir has an interior for containing fluid for being supplied to the microneedle assembly. The apparatus is adapted so that, when the apparatus is assembled, the reservoir is configured to move relative to the microneedle assembly along a path from an outer position to an inner position. The reservoir is closer to the microneedle assembly in the inner position than in the outer position. In the outer position, the reservoir is out of fluid communication with the microneedle assembly, and in the inner position, the reservoir is in fluid communication with the microneedle assembly. The apparatus also includes a plurality of connector parts spaced apart from one another along the path.

Transdermal drug delivery apparatus and methods

A gas extraction device for a fluid delivery apparatus includes a first layer and a vent membrane coupled to the first layer. The vent membrane enables a gas to pass through the vent membrane and prevents a fluid from passing through the vent membrane. The gas extraction device also includes a second layer coupled to the vent membrane opposite the first layer. The second layer has a first channel formed therethrough. In addition, the gas extraction device includes an impermeable membrane coupled to the second layer opposite the vent membrane. The first channel is configured to receive a fluid having a gas dispersed therein. The fluid is pressurized to move the fluid through the first channel against the vent membrane and to move the gas through the vent membrane.

Fluid delivery apparatus having a gas extraction device and method of use

An attachment band for a fluid delivery apparatus includes an annular body having a wall defining a hollow inner space, an adjacent pair of attachment apertures extending through the wall, and an indicator aperture extending through the wall opposite the pair of attachment apertures. The indicator aperture includes an indicator portion that is configured to present an indication to a user of the fluid delivery apparatus of a tightness of the attachment band. A first strap extends radially outward from the annular body of the attachment band and is substantially aligned with the attachment apertures. A second strap extends radially outward from the annular body and is substantially aligned with the indicator aperture.

Attachment band for a fluid delivery apparatus and method of use

A method for administering a medicament to a patient includes placing a fluid delivery apparatus with the medicament in contact with a portion of the skin of said patient. A flow rate of the medicament from the fluid delivery apparatus is adjusted such that the medicament is delivered to the patient for a predetermined time period. The fluid delivery apparatus includes a controller assembly having a body component defining an axis and a plunger component slidably coupled to the body component. The plunger is positionable between a first position in which the plunger is nearest to the body component and a second position in which the plunger component is furthest from the body component. A bias assembly is positioned between the body component and the plunger component. The bias assembly is configured to apply a two stage force profile to the plunger component.

Method for administering a medicament suitable for treating a migraine or cluster headache

A uniformity control membrane can be securely engaged against an upstream side of a microneedle array and configured so that resistance to flow through the uniformity control membrane is substantially greater than the resistance to flow through the microneedle array. These differences in flow resistance can facilitate uniform administration of a liquid formulation into the patient's skin across a broad area and at a relatively low pressure, such as by way of capillary action. The administration of the liquid formulation into the patient's skin across the broad area can result from the liquid formulation being administered by way of at least a majority of the microneedles of the microneedle array.

Microneedle array assembly, drug delivery device and method for administering liquid across a broad area at low pressure

A receptacle, which may be suitable for use as a portion of a transdermal drug delivery apparatus, may include a housing for being fastened to the user, a force provider that is elastic, at least one deformable component, and a microneedle assembly movably mounted to the housing for moving inwardly and outwardly relative to the housing. The force provider may be positioned between the housing and the microneedle assembly for forcing the microneedle assembly outwardly relative to the housing and against the skin of the user. The at least one deformable component may be connected between the microneedle assembly and the housing for both allowing relative movement between the microneedle assembly and the housing, and at least partially restricting the microneedle assembly from falling away from the housing. An arresting member may be positioned between the housing and the microneedle assembly for restricting any movement of at least tips of microneedles of the microneedle assembly into an interior of the housing.

Receptacle portion of transdermal drug delivery apparatus and methods

A cartridge, which may be suitable for use as a portion of a transdermal drug delivery apparatus, may include a body at least partially defining an interior for containing fluid for being delivered by the transdermal drug delivery apparatus. The body may also at least partially define first and second openings to the interior of the body, wherein the first and second openings are respectively proximate opposite first and second ends of the body. The cartridge may also include a self-sealing member at least partially closing the first opening, and a movable member at least partially closing the second opening, wherein at least a portion of the movable member is for being urged into the interior of the body for increasing pressure within the interior of the body.

Cartridge portion of transdermal drug delivery apparatus and methods

Growing community of inventors

Norcross, GA, United States of America

Andrew Thomas Baker