The University of British Columbia

Andrew Tarling

Raymond John Andersen

Stephen G Withers

Gary D Brayer

Leslie Karen Williams

Robert Keyzers

Christina Rose Tysoe

Katherine Woods

Provided are methods, uses and pharmaceutical compositions for inhibition of mammalian alpha-amylase in a subject, with a Helianthamide peptide or a derivative thereof in a biologically effective amount. The subject in need of alpha-amylase inhibition, may have or be at risk of developing one or more of the following: Middleton syndrome; a motility disorder of the gastrointestinal tract; postprandial reactive hypoglycemia; postprandial syndrome; irritable bowel syndrome; diabetes mellitus type 1; diabetes mellitus type 2; pre-diabetes; obesity, dumping syndrome; infant dumping syndrome; polycystic ovary syndrome; steatohepatitis; and viral infection.

Mammalian glucosidase inhibitors, methods for their use and pharmaceutical compositions thereof

Particular naturally occurring glycosylated acyl-flavonols are now shown to be effective mammalian &#x3b1;-amylase inhibitors. Such compounds can be obtained from plants of the genusand the compounds are useful in controlling starch digestion such as for management of glycemia in pre-diabetic or diabetic subjects, for management of obesity or for inhibiting oral caries or plaque formation.

Alpha-amylase inhibitors: the montbretins and uses thereof

Growing community of inventors

Vancouver, Canada

Andrew Tarling