Ivantis, Inc.

Alcon, Inc.

University of Colorado

Altaviz, LLC

Clarvista Medical, Inc.

Ocular Instruments, Inc.

Invantis, Inc.

Andrew T Schieber

John L Wardle

Charles L Euteneuer

Malik Y Kahook

Matthew Braden Flowers

Kenneth M Galt

Jack Robert Auld

Marcus Antonio Souza

Glenn R Sussman

Thomas R Hektner

Paul McLean

Edward Matthees

Sudarshan B Singh

Matthew D McCawley

Iqbal K Ahmed

Matthew Douglas Mccawley

John Wardle

Yule Kim

Nathaniel Z Zenz-Olson

John Christopher Huculak

Duane Frion

Rebecca McCarville

Diane M Feehan

Linda Thai

James Lescoulie

Raymond D Graham

Hector Truong

David T Van Meter

Rebecca Mccarville

Shane Sussman

Liam Dunphy

Nathaniel Zenz-Olson

Diane Feehan

Modular IOL systems including a base and a lens, wherein the lens includes fixed and actuatable tabs for connection to the base. The modular IOL allows for the lens to be adjusted or exchanged while leaving the base in place, either intra-operatively or post-operatively. Drug delivery capabilities and/or sensing capabilities may be incorporated into the base. Injector devices may be used to facilitate placement of the base and the lens sequentially or simultaneously into the eye.

Modular intraocular lens designs, tools and methods

An ocular implant delivery system is provided with a number of features. In some embodiments, the delivery system comprises a rotation mechanism configured to rotate and orient a cannula of the system, and an advancement mechanism configured to advance and retract an ocular implant through the delivery system and into an eye of a patient. In some embodiments, the cannula is sized and configured to be inserted into Schlemm's canal of the eye. The ocular implant is configured to maintain its orientation within the delivery system as the cannula is rotated. In some embodiments, the ocular implant automatically disengages the delivery system when it is advanced beyond a distal tip of the delivery system. Methods of implanting an ocular implant are also provided.

Single operator device for delivering an ocular implant

An ocular implant adapted to be disposed within Schlemm's canal of a human eye with a body extending along a curved longitudinal central axis in a curvature plane, a first strut on one side of the implant and a second strut on an opposite side of the implant, the circumferential extent of the first strut with respect to the plane of curvature being greater than the circumferential extent of the second strut with respect to the plane of curvature. The invention also includes methods of using the implant.

Apparatus for delivering ocular implants into an anterior chamber of the eye

Systems, methods, and devices for inserting an intraocular lens (IOL) assembly into an eye may be provided. An example optic management system may include a housing having a first end and a second end and a first side extending between the first end and the second end. The housing may include a cavity formed in the first side of the housing and configured to accommodate an intraocular lens, wherein the cavity comprises a first end portion, a second end portion, and a central portion. The housing may further include a bore formed in the housing, wherein a first portion of the bore extends from the first end to the cavity. The haptic optic management system may further include a ceiling disposed on the first side of the housing. The haptic optic management system may further include arms pivotably coupled to the housing in the cavity.

Haptic optic management system utilizing rotary arms

An ocular implant for treating glaucoma is provided, which may include any number of features. More particularly, the present invention relates to implants that facilitate the transfer of fluid from within one area of the eye to another area of the eye. One feature of the implant is that it includes a proximal inlet portion and a distal inlet portion adapted to be inserted into the anterior chamber of the eye, and an intermediate portion adapted to be inserted into Schlemm's canal. Another feature of the implant is that it can be biased to assume a predetermined shape to aid in placement within the eye.

Methods and apparatus for treating glaucoma

Ocular implants for delivery into an anterior chamber of the eye

A method of deploying an ocular implant into Schlemm's canal of an eye. The method includes the steps of inserting a distal end of a cannula through a cornea of the eye and into an anterior chamber of the eye, the cannula having a distal opening extending from the distal end and through a side wall; placing the distal opening of the cannula into fluid communication with Schlemm's canal; advancing the ocular implant distally through the cannula with a delivery tool engaged with the ocular implant, a proximal portion of the ocular implant engaging the delivery tool proximal to a distal portion of the delivery tool; and disengaging the ocular implant and the delivery tool when the proximal portion of the ocular implant reaches the cannula distal opening. The invention also includes a system for practicing the method.

Delivering ocular implants into the eye

An ocular implant having an inlet portion and a Schlemm's canal portion distal to the inlet portion, the inlet portion being disposed at a proximal end of the implant and sized and configured to be placed within an anterior chamber of a human eye, the Schlemm's canal portion being arranged and configured to be disposed within Schlemm's canal of the eye when the inlet portion is disposed in the anterior chamber.

Methods and devices for increasing aqueous humor outflow

A lacrimal drug delivery device includes a reservoir configured to hold a drug. The reservoir is moveable between a relaxed state and an expanded state. A connector is fluidly coupled to the reservoir and a lumen is formed in the connector wherein the drug is configured to flow from the reservoir to an delivery site through the lumen. A hydrogel is within the lumen and configured to absorb the drug from the reservoir and deliver the drug from the lumen at the delivery site. The hydrogel includes a first section which absorbs the drug at a first rate of absorption. A delivery guide is detachably coupled to the reservoir to deliver the reservoir into a lacrimal sac of a patient.

Lacrimal drug delivery device

Devices and methods are provided for delivering fluid into a patient's body. In an exemplary embodiment, the device may include a syringe cartridge and a syringe driver that may be coupled to the cartridge. The cartridge may include a housing including a proximal end, a distal end, and defining an interior, the cartridge further including a piston slidably disposed within the interior for delivering fluid within the interior through a port in the distal end. The driver may include a plunger for advancing the piston within the interior of the housing, a source of pressurized fluid, a valve, and an actuator member coupled to the valve for selectively opening a flow path from the source to the plunger to control flow of the pressurized fluid to advance the plunger to deliver fluid from the interior of the housing at a desired rate.

Self-powered syringe drivers

An illustrative method for reducing intraocular pressure in a patient may comprise deploying an ocular implant adapted to reside at least partially in a portion of Schlemm's canal of an eye and administering a therapeutic agent comprising a Rho kinase (ROCK) inhibitor to the patient. The ocular implant may be configured to lower the intraocular pressure from an initial to a second pressure within a first range and the therapeutic agent may lower an intraocular pressure to a third pressure within a second range, the third pressure lower than the second pressure.

Ocular implant and delivery system

Devices and methods are provided for delivering an agent into a patient's body using an injection device that includes a drive module and an injector module coupled to the drive module. The drive module includes a canister and puncture mechanism in a first chamber, a plunger in a second chamber communicating with the first chamber, and an actuator that moves the puncture mechanism to cause a puncture pin thereon to penetrate a septum of the canister and cause the gas within the canister to flow through the first chamber around the canister, and into the second chamber. The injector module includes a piston slidably disposed within an agent chamber and coupled to the distal end of the plunger such that, when the plunger moves from a retracted position to an extended position, the piston is advanced within the agent chamber to deliver an agent therein into a patient's body.

Injection devices and methods for making and using them

This invention is in the field of medical intervention related to the lacrimal system. The invention relates to a lacrimal system device or system and methods of using the device for drug delivery to the eye, sinuses and/or periocular tissues.

Lacrimal system for drug delivery

Growing community of inventors

Irvine, CA, United States of America

Andrew T Schieber