E.i. Dupont De Nemours and Company

Andrew T Chiu

John J Duncia

Pancras C Wong

Victor J De Noble

Robert J Ardecky

Ruth Richmond Wexler

Victor J DeNoble

Petrus B Timmermans

Imidazole compounds such as 5-[4-(3-(N-isopropylamino)hydroxypropoxy)indole-2-carboxamidomethyl]-2-n-b utyl-1-[(2'-carboxybiphenyl-4-yl)methyl]-4-chloroimidazole and their pharmaceutically suitable salts are useful for treating central nervous system disorders, such as cognitive and learning disorders, mediated by angiotensin-II.

Treatment of central nervous disorders with imidazole compounds

4,5,6,7-Tetrahydro-1H-imidazo[4,5-c]pyridine derivatives such as 1-(4-amino-3-methylphenyl) methyl-5-diphenylacetyl-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-car boxylic acid are useful for treatment of CNS disorders, such as cognitive and learning disorders, mediated by angiotensin-II.

Specific inhibition of angiotensin-II binding to angiotensin-II receptor

Substituted pyrazole, pyrrole and triazole angiotensin-II-1 receptor antagonists and pharmaceutically acceptable salts thereof are useful for treating central nervous system disorders, such as cognitive and learning disorders, mediated by angiotensin-II.

Treatment of central nervous system disorders with pyrazole, pyrrole and

Substituted imidazoles such as 2-butyl-4-chloro-1-[(2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl]-5-(hydroxy methyl)imidazole and 2-butyl-4-chloro-1-[(2'-carboxybiphenyl-4-yl)-methyl]-5-(hydroxymethyl)imi dazole and pharmaceutically acceptable salts thereof are useful for treating central nervous system disorders, such as cognitive and learning disorders, mediated by angiotensin II.

Treatment of central nervous system disorders with imidazole

Substituted benzimidazoles such as 2-butyl-1-[(2'-carboxybiphenyl-4-yl)methyl]-6-chlorobenzimidazole and pharmaceutically acceptable salts thereof are useful for treating central nervous system disorders, such as cognitive and learning disorders, mediated by angiotensin II.

Treatment of central nervous system disorders with benzimidazole

Provided are 4,5,6,7-tetrahydro-1H-imidazo(4,5-c)-pyridine derivatives, methods for preparing them, pharmaceutical compositions containing them, and methods of using them to treat disorders of mammals mediated by AII type-2 receptors in the central nervous system.

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Landenberg, PA, United States of America

Andrew T Chiu